42300-67-4Relevant academic research and scientific papers
Hydrolysis rates of alkyl and aryl sulfinamides: evidence of general acid catalysis
Piggott, Andrew M.,Karuso, Peter
, p. 7452 - 7455 (2007)
Sulfinamides are important in enantioselective synthesis, as rare post-translational modifications of proteins and as isosteres of the amide bond. Little is known about the rates of hydrolysis for aliphatic sulfinamides or the mechanism of hydrolysis. In this Letter, we show that sulfinamides hydrolyse by predominantly a non-specific acid/base catalysis with phosphate buffer but by varying the buffer concentration, it was possible to determine the hydrolysis rates of a range of sulfinamides with water through non-linear least squares regression.
Sulfonimidates: Useful Synthetic Intermediates for Sulfoximine Synthesis via C-S Bond Formation
Matos, Priscilla Mendon?a,Lewis, William,Moore, Jonathan C.,Stockman, Robert A.
supporting information, p. 3674 - 3677 (2018/06/26)
Medicinally relevant sulfoximines are accessed from C-S coupling of sulfonimidates and commercially available organomagnesium reagents. Sulfonimidates are conveniently synthesized by oxidative alkoxylation of readily available sulfinamides. This constitutes a general C-S coupling approach for the synthesis of sulfoximines.
