423116-18-1

Basic information

• Product Name: 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE
• Synonyms: 2-((4-oxocyclohexyl)Methyl)-2H-indene-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-[(4-oxocyclohexyl)methyl]-;2-((4-Oxocyclohexyl)methyl)isoindoline-1,3-dione
• CAS NO: 423116-18-1
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.288
• Mol File: 423116-18-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 421.4°Cat760mmHg
• Flash Point: 193.2°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE(423116-18-1)
• EPA Substance Registry System: 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE(423116-18-1)

Safety Data

• Hazardous Substances Data: 423116-18-1(Hazardous Substances Data)

Usage

General Description

4-N-Phthaloylglyaminomethyl-cyclohexanone is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of cyclohexanone and contains a phthaloyl group, an amino group, and a glyaminomethyl group. This chemical compound has potential applications in the development of new drugs and materials due to its unique structure and properties. It is also used as a building block in the synthesis of other complex organic molecules. Additionally, its cyclohexanone backbone makes it a versatile and valuable intermediate in the chemical industry for the generation of various products. Research on 4-N-phthaloylglyaminomethyl-cyclohexanone continues to explore its potential uses and applications in different fields.

InChI:InChI=1/C15H15NO3/c17-11-7-5-10(6-8-11)9-16-14(18)12-3-1-2-4-13(12)15(16)19/h1-4,10H,5-9H2

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 
• 85-44-9 phthalic anhydride 
• 30482-25-8 (1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine 

Downstream Products

• 478841-18-8 2-((4-hydroxycyclohexyl)methyl)isoindoline-1,3-dione 
• 423116-20-5 2-{[4-(prop-2-enyloxyimino)cyclohexyl]methyl}isoindoline-1,3-dione 
• 423116-19-2 2-{[4-(hydroxyimino)cyclohexyl]methyl}isoindoline-1,3-dione 

Relevant articles and documents

Abolishing Dopamine D2long/D3Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2Receptor Agonists

3-(2-Amino-4-methylthiazol-5-yl)propyl-substituted carbamoylguanidines are potent, subtype-selective histamine H2receptor (H2R) agonists, but their applicability as pharmacological tools to elucidate the largely unknown H2R functions in the central nervous system (CNS) is compromised by their concomitant high affinity toward dopamine D2-like receptors (especially to the D3R). To improve the selectivity, a series of novel carbamoylguanidine-type ligands containing various heterocycles, spacers, and side residues were rationally designed, synthesized, and tested in binding and/or functional assays at H1-4and D2long/3receptors. This study revealed a couple of selective candidates (among others31and47), and the most promising ones were screened at several off-target receptors, showing good selectivities. Docking studies suggest that the amino acid residues (3.28, 3.32, E2.49, E2.51, 5.42, and 7.35) are responsible for the different affinities at the H2- and D2long/3-receptors. These results provide a solid base for the exploration of the H2R functions in the brain in further studies.

PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, Ra, Rb, Q1, and Q2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Synthesis of some unsymmetrical bridged terpyridines

Novel unsymmetrical terpyridines 1 and 2 are synthesized using intra- and intermolecular Michael additions as the key reactions, followed by the construction of the central pyridine ring. Terpyridine 1 represents a heretofore unknown hexacyclic ring system.