423154-81-8

Basic information

• Product Name: 1-(3-BROMOBENZYL)-PIPERAZINE
• Synonyms: 1-(3-BroMobenyl)piperazine 2HCl;1-[(3-bromophenyl)methyl]piperazine;Oprea1_497862;SBB003115
• CAS NO: 423154-81-8
• Molecular Formula: C₁₁H₁₅BrN₂
• Molecular Weight: 255.16
• Mol File: 423154-81-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.4°C at 760 mmHg
• Flash Point: 153°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 0.000178mmHg at 25°C
• Refractive Index: 1.575
• PKA: 9.13±0.10(Predicted)
• CAS DataBase Reference: 1-(3-BROMOBENZYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOBENZYL)-PIPERAZINE(423154-81-8)
• EPA Substance Registry System: 1-(3-BROMOBENZYL)-PIPERAZINE(423154-81-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 423154-81-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow liquid

InChI:InChI=1/C11H15BrN2/c12-11-3-1-2-10(8-11)9-14-6-4-13-5-7-14/h1-3,8,13H,4-7,9H2

Upstream product

• 110-85-0 piperazine 
• 823-78-9 meta-bromobenzyl bromide 
• 865314-27-8 tert-butyl 4-(3-bromobenzyl)piperazine-1-carboxylate 

Downstream Products

• 1421322-10-2 C₂₉H₂₈BrClN₆O 
• 1384110-81-9 C₂₃H₂₅BrN₆O₂ 

Relevant articles and documents

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Synthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I - The effect of aromatic substituents

As part of a research program to develop compounds with mixed dopamine D4 and serotonin 5-HT2A antagonist activity with potential for the treatment of schizophrenia, we report a family of compounds based on structural modification of the atypical antipsychotic, clozapine (2). The chemical synthesis, structural characterization and pharmacological evaluation of a series 4′-arylmethyl analogues of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.