423156-68-7

Basic information

• Product Name: 4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE
• Synonyms: OTAVA-BB BB7018801969;TIMTEC-BB SBB009341;ART-CHEM-BB B014222;CHEMBRDG-BB 3014222;AKOS B014222;4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE;4-[(2-fluorobenzyl)oxy]-3-methoxybenzaldehyde(SALTDATA: FREE);4-[(2-fluorophenyl)methoxy]-3-methoxybenzaldehyde
• CAS NO: 423156-68-7
• Molecular Formula: C₁₅H₁₃FO₃
• Molecular Weight: 260.26
• Mol File: 423156-68-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 393.3°C at 760 mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 2.15E-06mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE(423156-68-7)
• EPA Substance Registry System: 4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE(423156-68-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 423156-68-7(Hazardous Substances Data)

Usage

General Description

4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE is a chemical compound with the molecular formula C15H13FO3. It is an aldehyde compound that contains a fluorobenzyl group attached to an oxygen atom, which is in turn attached to a methoxybenzaldehyde group. This chemical is commonly used in organic synthesis and pharmaceutical research due to its unique structure and potential pharmacological properties. It is important to handle this compound with care as it may have toxic or hazardous properties.

InChI:InChI=1/C15H13FO3/c1-18-15-8-11(9-17)6-7-14(15)19-10-12-4-2-3-5-13(12)16/h2-9H,10H2,1H3

Upstream product

• 345-35-7 2-fluorobenzyl chloride 
• 121-33-5 vanillin 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 883975-25-5 tert-butyl [2-({4-[(2-fluorobenzyl)oxy]-3-methoxybenzyl}amino)ethyl]carbamate 

Relevant articles and documents

3-methyl pyridino-[1,2-a] pyrimidone derivative containing 1-((4-benzyl-substituted)oxygroup) and application

The invention discloses a 3-methyl pyridino-[1,2-a] pyrimidone derivative containing 1-((4-benzyl-substituted)oxygroup) and application. The general formula of the derivative is shown in the description, wherein R1 is a methoxyl group or an oxyethyl group or halogen; R2 is hydroxyl or isobutyl or ethyl or propyl or chloroethyl or 2-methoxyl group benzyl or 2-methoxyl group benzy or 2-fluorine benzyl or 2-cyanogroup benzyl chloride or 4-cyanogroup benzyl2-methyl benzyl chloride or 3-methyl benzyl chloride or 4-methyl benzyl chloride. According to the derivative, the rice bacterial leaf blight and citrus canker can be prevented and treated. The general formula is shown in the description.

Biological evaluation and in silico molecular docking study of a new series of thiazol-2-yl-hydrazone conglomerates

A new series of hybridized thiazol-2-yl-hydrazone derivatives having diverse substituents were designed, synthesized, and screened for their anti-inflammatory property by a carrageenan-induced paw edema method. The compounds 11a, 11b, 11c, 11d, 11e, 11g, 11m and 11p revealed significant inhibition when compared to Diclofenac sodium. Subsequently, two highly potent compounds (11d and 11e) were evaluated for their cytotoxic effect on the tumor cell line. The binding interactions of thiazol-2-yl-hydrazones with the cyclooxygenase-2 (COX-2) protein (PDB: 3LN1) displayed effective interactions with Arg-120, Tyr-385 and Tyr-355 amino acids, the main criteria of the COX-2 inhibitor. In addition, all the compounds showed moderate to good in vitro antibacterial activity. Most active benzyloxy derivatives were also tested to understand the radical scavenging efficacy by the 2,2-diphenyl-1-picrylhydrazyl method. Graphical Abstract: [Figure not available: see fulltext.].

SUBSTITUDED BENZYLOXY-PHENYLMETHYLUREA DERIVATIVES

The present invention relates to novel substituted benzyloxy-phenylmethylurea derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR