423166-07-8

Upstream product

• 423166-05-6 2-[(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)amino]ethanol 
• 350604-58-9 tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane 
• 254108-49-1 2-fluoro-4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 423166-09-0 4-[(5-{[(2R)-4-(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)-2-methyl-3-oxopiperazin-1-yl]carbonyl}-1H-imidazol-1-yl)methyl]-2-fluorobenzonitrile 
• 423166-08-9 N-(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)-1-(4-cyano-3-fluorobenzyl)-N-(2-oxoethyl)-1H-imidazole-5-carboxamide 

Relevant academic research and scientific papers

Preparation of Substituted Piperazinones via Tandem Reductive Amination-(N,N′-Acyl Transfer)-Cyclization

matrix presented A one-pot, tandem reductive amination-transamidation-cyclization reaction was employed to produce substituted piperazin-2-ones in good yields. Various amino acid methyl esters and transferable acyl groups were examined to establish the re