4237-25-6Relevant academic research and scientific papers
Selective process for preparting 2,4- or 3,6-di-substituted phenol compounds
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, (2008/06/13)
A selective process for preparing a 2,4- or 3,6-di-substituted phenol compound which comprises reacting an olefin compound of the formula: STR1 wherein R1 is hydrogen, halogen, alkyl, halogen substituted alkyl, aryl, halogen substituted-aryl or alkyl substituted-aryl; and R2, R3 and R4 are the same or different and each is hydrogen, halogen, alkyl, halogen substituted-alkyl or aralkyl; with a phenol compound of the formula: STR2 wherein R5 is hydrogen, hydroxy, halogen, alkyl, halogen substituted-alkyl, alkoxy or --C(R6)(R7)CH(R8)(R9) (wherein R6 is hydrogen, halogen, alkyl, halogen substituted-alkyl, aryl, halogen substituted-aryl or alkyl substituted-aryl; and R7, R8 and R9 are the same or different and each is hydrogen, halogen, alkyl, halogen substituted-alkyl or aralkyl), in the presence of a phosphorus compound and a carboxylic acid compound as catalysts. The methods of the present invention, which is used a phosphorus compound and a carboxylic acid compound as catalysts, are enable to make the separation procedures easy, make the reaction process and time short, not to produce any colored resultant product, and reduce that cost in manufacturing procedures.
