423772-41-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 188359-36-6 (3S,4R,5S,6S,9R,10S)-10-((2R,3R)-5-Methoxy-3-methyl-tetrahydro-furan-2-yl)-4,6-dimethyl-3,5-bis-triethylsilanyloxy-undecane-1,9-diol 

Downstream Products

• 423772-46-7 (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-1-trityloxy-tetradecan-4-ol 
• 423772-45-6 (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol 
• 423772-44-5 (2R,3R)-2-[(1S,2R,5S,6S,7R,8S)-6,8-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(tert-butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxymethoxy)-1,5,7-trimethyl-decyl]-5-methoxy-3-methyl-tetrahydro-furan 
• 423772-43-4 (3S,4R,5S,6S,9R,10S)-1-(tert-Butyl-diphenyl-silanyloxy)-9-(3,4-dimethoxy-benzyloxymethoxy)-10-((2R,3R)-5-methoxy-3-methyl-tetrahydro-furan-2-yl)-4,6-dimethyl-undecane-3,5-diol 
• 423772-42-3 (2R,3R)-2-[(1S,2R,5S,6S,7R,8S)-10-(tert-Butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxymethoxy)-1,5,7-trimethyl-6,8-bis-triethylsilanyloxy-decyl]-5-methoxy-3-methyl-tetrahydro-furan 

Relevant academic research and scientific papers

Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs

Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.