42389-40-2

Usage

Uses

Used in Pharmaceutical Development:
2-(1H-benzimidazol-2-ylamino)-6-methylpyrimidin-4(1H)-one is utilized as a candidate for drug development due to its ability to inhibit certain enzymes and receptors in the body. This makes it a valuable asset in the creation of new medications targeting specific biological pathways.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(1H-benzimidazol-2-ylamino)-6-methylpyrimidin-4(1H)-one serves as a subject of study for understanding its potential interactions with biological systems. Its unique structure allows researchers to investigate its properties and how it can be harnessed for therapeutic purposes.

Upstream product

• 5418-95-1 2-guanidinobenzimidazole 
• 105-45-3 acetoacetic acid methyl ester 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists

A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed.

Synthesis and Mass Spectra of Some Substituted 2-(2'-Benzazolylamino)pyrimidines

Three series of title compounds, viz. 2-(2'-benzazolylamino)-4,6-dimethylpyrimidines (I), 2-(2'-benzazolylamino)-4-hydroxy-6-methylpyrimidines (II) and 2-(2'-benzazolylamino)-5,6-cyclopenteno-4-hydroxypyrimidines (III) have been synthesized by condensing 2-guanidinobenzazoles (V) with pentane-2,4-diones, ethyl acetoacetates and 2-carbethoxycyclopentanone, respectively.Mass spectra studies reveal that there is an initial fragmentation of pyrimidine ring in I via two competitive processes involving either the loss of methyl cyanide followed by methyl group or vice versa.This mode of fragmentation, however, is completely suppressed in the presence of a methoxyl substituent in the benzothiazole ring which triggers an alternative low-energy pathway.No loss of methyl cyanide or methyl group has been ovbserved in the mass spectra of II, rather the pyrimidine ring undergoes fission resulting in the initial loss of formyl radical.Several of these compounds exhibit significant anti-inflammatory activity.