42393-16-8Relevant academic research and scientific papers
Ionic Liquid [BDBDMIm](Br3)2 As a New Efficient Brominating Agent in the Synthesis of γ-Butyrolactones
Fekri
, p. 1009 - 1014 (2018/07/06)
γ-Butyrolactones can be synthesized by a solvent free multicomponent reaction of aldehydes with ethylpyruvate followed by an intramolecular cyclization using the new brominating agent, ionic liquid [BDBDMIm](Br3)2. This is the first synthesis of γ-butyrolactones starting with aldehydes via the Knovenagel condensation and halogenation, followed by multicomponent cyclization reaction. The present method offers several advantages such as solvent free mild conditions, simple procedure, excellent yields, and environmental friendliness. All synthesized compounds were characterized by their IR, 1H and 13C NMR spectra.
Synthesis of some substituted furan-2(5H)-ones and derived quinoxalinones as potential anti-microbial and anti-cancer agents
El-Tombary, Alaa A.,Abdel-Ghany, Yasser S.,Belal, Ahmad S.F.,Shams El-Dine, Shams A.,Soliman, Farid S.G.
, p. 865 - 876 (2012/05/04)
In search for novel anti-cancer and antimicrobial agents with promising pharmacotoxicological profile, the synthesis of some substituted 4-halofuran- 2(5H)-ones (8a-l, 9, 11) and derived halogenated quinoxalin-2(1H)-ones (12a-d) is described. Some of the halogenated furanones were readily oxidized to the corresponding 2-bromo-2-propenoic acids (13a-c) with hydrogen peroxide in alkaline medium. Twenty-two compounds were preliminary tested for their in vitro activity against three bacteria and one fungus and revealed encouraging activity. On the other hand, three compounds were screened as anti-cancer agents using cell line panel protocol and 22 compounds were subjected to cycline-dependent kinases (CDKs) inhibition screening program but were inactive. Springer Science+Business Media, LLC 2010.
