42399-86-0Relevant articles and documents
An Unequivocal Synthesis of Some Substituted 1,2,4-TriazoloPyrimidines
Stanovnik, Branko,Urleb, Uros,Tisler, Miha
, p. 601 - 606 (2007/10/02)
An unequivocal synthesis of 5-chloro-7-methyl- (8) and 7-methyl-1,2,4-triazolopyrimidine (10) from 2-amino-4-chloro-6-methylpyrimidine (5) through the corresponding amidine 6 and formamide oxime 7 was developed.It was unambigously shown by comparison of the chemical shifts and the magnitude of coupling constants that the compounds obtained by condensation of 3-amino-1,2,4-triazole (12) and ethyl acetoacetate (13) and some further transformations are isomeric 5-methyl substituted 1,2,4-triazolopyrimidines 1, 9, and 11. - Keywords: 1,2,4-Triazolopyrimidines; Cyclization with N-N bond formation; Structure determination by NMR