42404-23-9

Basic information

• Product Name: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE
• Synonyms: {2-[(4-methylphenyl)thio]ethyl}amine;2-[(4-methylphenyl)thio]ethanamine(SALTDATA: FREE);1-Amino-2-p-tolylthioethane;2-(4-methylphenyl)sulfanylethanamine;2-[(4-Methylphenyl)sulfanyl]ethanamine
• CAS NO: 42404-23-9
• Molecular Formula: C₉H₁₃NS
• Molecular Weight: 167.27
• Mol File: 42404-23-9.mol

Chemical Properties

• Boiling Point: 267.2°Cat760mmHg
• Flash Point: 115.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.00826mmHg at 25°C
• PKA: 8.87±0.10(Predicted)
• CAS DataBase Reference: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(42404-23-9)
• EPA Substance Registry System: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(42404-23-9)

Safety Data

• Hazardous Substances Data: 42404-23-9(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
4-MTA is used as a research chemical for studying the effects of psychoactive substances on the central nervous system. Its activity as a serotonin-norepinephrine-dopamine releasing agent and a serotonin receptor agonist makes it a valuable tool for understanding the mechanisms of action of amphetamine-based stimulants.
Used in Drug Enforcement and Forensic Analysis:
Due to its classification as a Schedule I controlled substance in the United States, 4-MTA is used in drug enforcement and forensic analysis to identify and track the distribution of illicit substances. Its detection helps law enforcement agencies combat the illegal use and trafficking of this potentially dangerous drug.

InChI:InChI=1/C9H13NS/c1-8-2-4-9(5-3-8)11-7-6-10/h2-5H,6-7,10H2,1H3/p+1

Upstream product

• 4528-34-1 2-nitroethanol nitrate 
• 10486-08-5 sodium p-thiocresolate 
• 87943-20-2 2-phthalimidoethyl p-tolyl sulphide 
• 497-25-6 dimethylenecyclourethane 
• 106-45-6 para-thiocresol 
• 870-24-6 2-chloroethanamine hydrochloride 
• 13989-86-1 2-chloroethylcarbamic acid methyl ester 
• 82772-76-7 N-<2-<(4-methylphenyl)thio>ethyl>propanamide 
• 2576-47-8 2-bromoethylamine hydrobromide 

Downstream Products

• 53492-62-9 4-methyl-3-[2-(toluene-4-sulfinyl)-ethyl]-sydnone 
• 133760-87-9 1-Phenyl-2-(2-p-tolylsulfanyl-ethylamino)-ethanol 
• 361145-76-8 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(4-methylphenyl)thio]ethyl}-1-isoindolinone 
• 133760-77-7 5-Phenyl-3-(2-p-tolylsulfanyl-ethyl)-oxazolidin-2-one 
• 133760-81-3 4-Phenyl-1-(2-p-tolylsulfanyl-ethyl)-imidazolidin-2-one 
• 115335-19-8 Benzyl-(2-p-tolylsulfanyl-ethyl)-amine 
• 1186400-98-5 benzyl (2-(p-tolylthio)ethyl)carbamate 
• 66860-00-2 2-phenyl-3-(2-p-tolylsulfanyl-ethyl)-thiazolidin-4-one 
• 64276-34-2 2-<<2-<(4-methylphenyl)thio>ethyl>amino>-propanoic acid 
• 66859-96-9 benzylidene-(2-p-tolylsulfanyl-ethyl)-amine 

Relevant articles and documents

PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES

The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reac

Syntheses of 1,4-benzothiazepines and 1,4-benzoxazepines via cyclizations of 1-[2-arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones

1-[2-Arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones 6a-e, 12 and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones 9a-f, 14 are readily available from reactions of benzotriazole (4), 2-(arylsulfanyl)ethylamines 3, or 2-phenoxyethylamine (11) with 2,5-dimethoxy-2,5-dihydrofuran (5) or 2-formylbenzoic acid (8). Lewis acid mediated cyclizations of 6 and 9 produced novel 1,4-benzothiazepines 7a-e and 10a-f, respectively. Cyclizations of 12 and 14 gave 1,4-benzoxazepines 13 and 15, respectively.

Base-promoted aminoethylation of thiols with 2-oxazolidinones: A simple synthesis of 2-aminoethyl sulfides

A simple synthesis of 2-aminoethyl sulfides using a base-promoted reaction of 2-oxazolidinones with thiols is described. An application of this method to the synthesis of chiral 2-aminoethyl sulfides and sulfur-containing heterocyclic compounds is also presented.

A Simple Synthesis of β-Amino Sulfides

Thiols reacted with 2-oxazolidinones in the presence of alkoxides to give β-amino sulfides in high yields. The method was applied to the synthesis of 5,6-dihydro-1,4-thiazin-3(2H)-ones.