42407-83-0

Upstream product

• 91-56-5 indole-2,3-dione 
• 123-30-8 4-amino-phenol 

Downstream Products

• 91870-69-8 3'-(4-hydroxyphenyl)-5'-methyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione 
• 91-56-5 indole-2,3-dione 
• 123-30-8 4-amino-phenol 

Relevant academic research and scientific papers

Synthesis of 1,3-diaryl-spiro[azetidine-2,3′-indoline]-2′,4-diones: Via the Staudinger reaction: Cis - Or trans -diastereoselectivity with different addition modes

A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3′-indoline]-2′,4-diones was developed based on Staudinger ketene-imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and an organic base. A series of [azetidine-2,3′-indoline]-2′,4-diones were synthesized using this method. For comparison, the same compounds were obtained using a known technique, where ketene is generated from pre-synthesized acyl chloride. It was shown that the use of oxalyl chloride for ketene generation in the one-pot reaction at room temperature allows for the reversal of the diastereoselectivity of spiro-lactam formation, unlike previously described procedures.

Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents

An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considering the advantage microwave synthesis in terms of high efficient energy, indole derivatives are prepared. In the current study, the Schiff's bases are first synthesized by reaction of 1H-indole-2,3-dione (isatin) with various substituted anilines in presence of acetic acid under microwave irradiation. Then the Mannich bases are produced by condensation of Schiff bases with different secondary amines in the presence of formaldehyde. The newly synthesized compounds are characterized by TLC report and spectral data followed by evaluation for anthelmintic activity against Pheretima posthuma. Albendazole is used as standard drug for comparative study. The titled compounds are screened for anthelmintic activity at the concentration of 10, 20 and 50 mg/ml. The anthelmintic effect of standard drug Albendazole is also evaluated at 10 mg/ml. The results of present study indicate that some of the tested compounds exhibit significant anthelmintic activity in dose dependent manner.

Synthesis, cytoprotective and anti-Tumor activities of Isatin Schiff bases

A series of simple isatin Schiff bases were synthesized through the condensation reaction. These isatin Schiff bases were characterized by NMR and MS, and the structure was discussed. Then, the cytoprotective and anti-Tumor activities of these compounds were evaluated. The results show that several compounds show protection activity on the apoptosis of PC12 cells induced by H2O2, which are more effective than that of (±) α-Tocophreol (VE) and isatin. Besides, some compounds also show more potent anti-Tumor activity against A549 and P388 cell lines than that of isatin.

Synthesis and application of 3-(4-hydroxyphenylimino)indolin-2-one as corrosion inhibitor

A isatin Schiff base, 3-(4-hydroxyphenylimino)indolin-2-one, was synthesized and analyzed by NMR and MS. The inhibition and the mechanism of the title compound on the corrosion of high protective Q235A steel in HCl solution were screened and discussed. The results indicated that it can inhibit the corrosion with moderate inhibition efficiency in different conditions, and the inhibition mechanism of the corrosion inhibiting may be mainly contributed to the adsorption. Potentiodynamic polarization studies indicate that extracts are mixed-type inhibitors. While the title compound was companied with hexamethylenetetramine (HMTA) and 1,4-dihydroxy-2-butyne (BOZ), the inhibition efficiency was enhanced effectively.

Synthesis and application of isatin schiff base as corrosion inhibitor

Isatin Schiff base, 3-(4-hydroxyphenylimino)indolin-2-one, was synthesized and analyzed by NMR and MS. The inhibition and the mechanism of the title compound on the corrosion of high protective Q235A steel in HCl solution were screened and discussed. The

Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

A set of novel Schiff bases of isatin were synthesized and characterized by reaction of isatin with various aromatic or heterocyclic primary amines. Cytotoxic activities for some of the synthesized compounds were evaluated byMTTassay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in HeLa cells. 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one was found to be the most potent molecule among the studied isatin derivatives. Docking studies of 3-substituted indolin-2-one scaffolds on vascular endothelial growth factor receptor 2 (VEGFR-2) involved in cell proliferation and angiogenesis was performed. 3-(naphthalen-1-ylimino) indolin-2-one and 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one exhibited higher docking binding energies with receptor. For 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one, H-bond interaction with Cys917 residue of target active site was in common with reported crystallographic benzoimidazole derivative (PDB code: 2OH4). New key H-bonds involving Glu915, Asn921, and Arg1049 residues in VEGFR-2 active site could be detected for 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one. Extended lipophilic rings containing H-bond acceptors on the 3 position of indoline scaffold seemed to be important factors in developing potent VEGFR-2 inhibitors virtually. Based on the ligand efficiency indices, some isoxazole or thiazole substituted isatin derivatives may be regarded as efficient candidates for further molecular developments of anticancer agents. Springer Science+Business Media, LLC 2011.

Some isatin Schiff bases as corrosion inhibitors for iron in sulphuric acid solution

Six isatin Schiff bases have been prepared and treated as inhibitors for the corrosion of iron in 1 mol L-1 sulphuric acid.The inhibitor efficiencies calculated from weight loss and polarization methods are in good agreement.The Tafel slope is