42424-50-0

Basic information

• Product Name: POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT
• Synonyms: POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;POLY I POLY C, NA;POLY[I] POLY[C] SODIUM SALT;Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double;polyinosinic-polycytidylic acid sodium;Poly(I) •
• CAS NO: 42424-50-0
• Molecular Formula: (C10H13N4O8P)x·(C9H14N3O8P)x
• Molecular Weight: 671.41
• EINECS: 1308068-626-2
• Product Categories: Biochemicals and Reagents;Biomaterials;Cell Culture;Materials Science;Nucleosides;Nucleotides;Oligonucleotide Polymers and Copolymers;Oligonucleotides;Other adjuvants;Synthetic Oligonucleotides and Related Reagents;Vaccine Adjuvants;Vaccine Production
• Mol File: 42424-50-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: H2O: soluble10mg/mL
• CAS DataBase Reference: POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT(42424-50-0)
• EPA Substance Registry System: POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT(42424-50-0)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: TR0175000
• Hazardous Substances Data: 42424-50-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 42424-50-0 differently. You can refer to the following data:
1. TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
2. Polyinosinic Acid & Polycytidylic Acid Sodium Salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.

Biological Activity

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.