42426-35-7Relevant academic research and scientific papers
Unidirectional triple hydrogen rearrangement in the radical cations of electron-rich 3-aryl-1-propanols: Further evidence and limitation
Kuck, Dietmar,Salameh, Linda C.,Onwuka, Kenneth I.,Letzel, Matthias C.
, p. 51 - 61 (2014)
The unidirectional triple-hydrogen (3H) rearrangement of the radical cations of 3-aryl-1-propanols bearing an electron-rich substitutent in the para-position was investigated for the diastereomeric 2-(4-dimethylamino) benzylcyclohexanols and 2-(4-dimethyl
Synthesis of 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes from the same reactants by using metal-free catalyst
Naeimi, Hossein,Mohammadi, Somaye
supporting information, p. 50 - 59 (2019/12/27)
A facile and rapid multicomponent synthesis of pharmaceutically diverse 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes has been developed from benzaldehyde, malononitrile, and cyclohexanone. Three different methods from the same reactants, solvent, temperature, and catalyst lead to three products with excellent yields. All the reactions were followed with the Michael addition and cyclization. In this study, morpholine was used as an active metal-free base catalyst that increases the yields of products and decreases the time of reactions.
Functionalized CoFe2O4/lamellar mesopore silica anchored to melamine nanocomposite as a novel catalyst for synthesis of 4H-chromenes under mild conditions
Mohammadi, Somaye,Naeimi, Hossein
, (2020/03/24)
In this research, it was displayed an efficient method for the one-pot reaction of cyclohexanone, benzaldehyde and malononitrile for the synthesis of 4H-chromenes by using CoFe2O4/lamellar mesopore silica anchored to melamine as a magnetic nanocatalyst. This nanocatalyst was prepared in several steps and discriminated by XRD, FT-IR, SEM, VSM, TGA and BET techniques. The catalyst has a large active base site that has functionalized in both the surface and the pore of nanostructure. The advantages of magnetic nanocatalyst were simple accessible, heterogeneous nanocatalyst, easy work up and reusability. The various derivatives of 4H-chromenes were synthesized in the presence of CoFe2O4/lamellar mesopore silica/melamine magnetic nanocatalyst with the excellent yields and appropriate times. The products were identified by the melting point, FT-IR, 1H NMR, 13C NMR and C.H.N techniques.
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, Janos,Wagner, Gabor,Nogradi, Katalin,Bielik, Attila,Molnar, Laszlo,Bobok, Amrita,Horvath, Attila,Kiss, Bela,Kolok, Sandor,Nagy, Jozsef,Kurko, Dalma,Bakk, Monika L.,Vastag, Monika,Saghy, Katalin,Gyertyan, Istvan,Gal, Krisztina,Greiner, Istvan,Szombathelyi, Zsolt,Keser, Gyoergy M.,Domany, Gyoergy
scheme or table, p. 4371 - 4375 (2010/10/02)
Hit-to-lead optimization of a HTS hit led to new carbamoyloxime derivatives. After identification of an advanced hit (8d) the CYP enzyme inhibitory activity of this class of compounds was successfully eliminated. Systematic exploration of different parts of the advanced hit led us to some promising lead compounds with mGluR5 affinities comparable to that of MPEP.
STEREOCHEMICAL INVESTIGATIONS. XXVII. CONFORMATIONAL EFFECT OF THE PREDOMINANCE OF THE AXIAL CONFORMER IN 2-SUBSTITUTED BENZYLIDENECYCLOHEXANES
Zefirov, N. S.,Baranenkov, I. V.
, p. 2112 - 2118 (2007/10/02)
The conformational equilibrium in the compounds was investigated by dynamic PMR spectroscopy, and the effect of the polarity of the solvent was studied.A comparative analysis was made of the conformational behavior of the 2-substituted benzylidenecyclohex
