42427-51-0Relevant academic research and scientific papers
Catalytic, contra-Thermodynamic Positional Alkene Isomerization
Occhialini, Gino,Palani, Vignesh,Wendlandt, Alison E.
supporting information, p. 145 - 152 (2022/01/19)
The positional isomerization of C═C double bonds is a powerful strategy for the interconversion of alkene regioisomers. However, existing methods provide access to thermodynamically more stable isomers from less stable starting materials. Here, we report
Electrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives
Zhao, Bin,Pan, Zichen,Zhu, Anqiao,Yue, Yanni,Ma, Mengtao,Xue, Fei
supporting information, (2022/01/24)
Herein, we report a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources (RSO2NHNH2) and Et3N·3HF as cost-effective fluorination reagents under mild conditions. Remarkably, this
Cobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes
Zhang, Sheng,Bedi, Deepika,Cheng, Lu,Unruh, Daniel K.,Li, Guigen,Findlater, Michael
supporting information, p. 8910 - 8917 (2020/12/23)
Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic chemistry, due to the small energy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted alkenes). Transition metal-catalyzed isomerization of 1,1-disubstituted alkenes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped owing to issues relating to reaction efficiency and stereoselectivity. Here we show that a novel cobalt catalyst can overcome these challenges to provide an efficient and stereoselective access to a broad range of trisubstituted alkenes. This protocol is compatible with both mono- and dienes and exhibits a good functional group tolerance and scalability. Moreover, it has proven to be a useful tool to construct organic luminophores and a deuterated trisubstituted alkene. A preliminary study of the mechanism suggests that a cobalt-hydride pathway is involved in the reaction. The high stereoselectivity of the reaction is attributed to both a π-πstacking effect and the steric hindrance between substrate and catalyst.
Iridium-catalyzed enantioselective hydrogenation of terminal alkenes
McIntyre, Steven,Hoermann, Esther,Menges, Frederik,Smidt, Sebastian P.,Pfaltz, Andreas
, p. 282 - 288 (2007/10/03)
Iridium complexes derived from chiral P,N ligands are efficient catalysts for the enantioselective hydrogenation of 2-aryl-substituted terminal alkenes. Using 0.1-1 mol % of catalyst at room temperature and ambient hydrogen pressure, high enantioselectivi
