42438-75-5Relevant academic research and scientific papers
Total synthesis and pharmaceutical composition comprising a novel prenylated tetracyclic synthetic intermediate of sericetin preventing drug-induced nephrotoxicity
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, (2020/06/10)
The present invention relates to a novel sericetin total synthesis method exhibiting drug-induced kidney damage protection activity and to a pharmaceutical composition containing novel sericetin as an active component. More specifically, the present invention provides a synthesis method for improving a synthesis yield of sericetin and a use of an intermediate (a compound 14) produced during the synthesis process as a therapeutic agent for drug-induced kidney damage by confirming protective activity on drug-induced kidney damage.COPYRIGHT KIPO 2020
Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
Kim, Eun-Sun,Jang, Hongjun,Chang, Sun-Young,Baek, Seung-Hoon,Bae, Ok-Nam,Kim, Hyoungsu
, p. 2647 - 2653 (2019/01/04)
A concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.
