42460-61-7

Basic information

• Product Name: 4-Amino-2-chlorobenzaldehyde
• Synonyms: 4-Amino-2-chlorobenzaldehyde
• CAS NO: 42460-61-7
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Mol File: 42460-61-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Amino-2-chlorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-chlorobenzaldehyde(42460-61-7)
• EPA Substance Registry System: 4-Amino-2-chlorobenzaldehyde(42460-61-7)

Safety Data

• Hazardous Substances Data: 42460-61-7(Hazardous Substances Data)

Upstream product

• 121-86-8 2-chloro-4-nitrotoluene 
• 64-17-5 ethanol 
• 51420-25-8 4-amino-2-chloro-benzyl alcohol 
• 20925-27-3 4-amino-2-chlorobenzonitrile 

Downstream Products

• 937040-28-3 1-(3-chloro-4-formyl-phenyl)-3-(3-fluoro-phenyl)-urea 
• 1333480-82-2 (5Z)-5-(4-amino-2-chlorobenzylidene)imidazolidine-2,4-dione 
• 69828-55-3 N-(3-chloro-4-formylphenyl)acetamide 
• 87743-91-7 4-amino-2-chloro-benzaldehyde-thiosemicarbazone 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Synthesis of 4-Aminobenzoic Aldehydes.

In the reported research program, studies have been carried out on the reaction of oxidation-reduction of 4-nitrotoluene (NT) and 2-chloro-4-nitrotoluene (CNT) resulting in aminobenzaldehydes and toluidines, respectively. The optimum conditions have been elaborated (the ratio of S:Na//2S and Na//2S//x:nitrotoluene) of carrying on the processes enumerated. It has been established that introduction of a halide in ortho position of methyl group in 4-nitrotoluene brings about a considerable acceleration of the oxidation-reduction reaction leading to aminoaldehyde, but without any influence of the rate of reduction in the result of which toluidine is obtained.