42466-67-1

Basic information

• Product Name: (E)-Ethyl 2-cyano-3-ethoxyacrylate
• Synonyms: ethyl (E)-2-cyano-3-ethoxyacrylate
• CAS NO: 42466-67-1
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.17784
• Mol File: 42466-67-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 128-132 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.075±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (E)-Ethyl 2-cyano-3-ethoxyacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Ethyl 2-cyano-3-ethoxyacrylate(42466-67-1)
• EPA Substance Registry System: (E)-Ethyl 2-cyano-3-ethoxyacrylate(42466-67-1)

Safety Data

• Hazardous Substances Data: 42466-67-1(Hazardous Substances Data)

Usage

General Description

"(E)-Ethyl 2-cyano-3-ethoxyacrylate" is a specialized chemical compound that belongs to the class of organic compounds known as nitriles. Nitriles are compounds containing a cyano functional group that's linked to a carbon atom. The "(E)" indication in the compound's name refers to its geometric isomer configuration around the double bond in the molecule, where the highest priority groups are on opposite sides. This chemical compound is primarily used as an intermediary component in the synthesis of other complex chemical compounds in industries such as pharmaceuticals and agrochemicals. As with handling most chemical compounds, precautions must be taken to prevent exposure or ingestion which may pose health threats.

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 92672-33-8 2-cyano-3-(1H-[1,2,4]triazol-3-ylamino)-acrylic acid ethyl ester 
• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 
• 109818-19-1 2-cyano-3-diethylphosphonoprop-2-enoate d'ethyle 
• 14678-87-6 ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate 
• 215438-75-8 methyl 3-amino-4-ethoxycarbonyl-1-methyl-1H-pyrrole-2-carboxylate 
• 227176-38-7 7-ethoxycarbonyl-3-phenyl-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione 
• 89487-99-0 4-hydroxy-2-methylsulfanylpyrimidine-5-carbonitrile 

Relevant articles and documents

SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)

Condensation of ethyl (ethoxymethylene)cyanoacetate with Acyl- and diphenylphosphinylhydrazines

Condensation of ethyl (ethoxymethylene)cyanoacetate with hydrazides of diphenylphosphinic acid and aliphatic and aromatic acids in ethanol involves exclusively the ethoxymethylene group and yields the corresponding ethyl 3-oxo-2-cyanopropanoate hydrazones. These compounds exist in the crystalline state and in solutions in the form of the enehydrazine tautomer in which the configurational equilibrium is determined by the nature of substituent in the hydrazine moiety.