4247-19-2Relevant academic research and scientific papers
Synthesis and enantioselective gas chromatography of stereoisomers of 7,11-dimethylheptadecane - A pheromone component of Lambdina species
Chow, Sharon,Koenig, Wilfried A.,Kitching, William
, p. 1198 - 1201 (2004)
The stereoisomers of 7,11-dimethylheptadecane exhibit a useful level of separation under enantioselective gas chromatographic conditions, using a modified cyclodextrin phase. Synthesis of the (7R,11R) isomer and coinjection studies establish the order of elution as (7S,11S), (7R,11R), and finally the meso form, the latter being a sex-pheromone component of Lambdina species. Enantiomeric assays of natural samples containing this hydrocarbon system will now be possible. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
One-pot method for preparing diepoxide (by machine translation)
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Paragraph 0101-0108, (2020/05/01)
The method comprises the following steps, adding a reducing agent water solution :S1. to a reactor: slowly dropwise adding a reducing agent aqueous solution to obtain the diepoxide, adding a reducing agent aqueous solution to the reactor, to obtain the diepoxy, and separating and purifying ;S2. from the organic phase: by one-pot reaction, and adding a reducing agent water, through a pot method to obtain the diepoxide crude solution, to obtain the diepoxide compound. The invention discloses a method for separating and purifying a diepoxide crude product through a high vacuum, distillation . The method comprises the following steps of: adding a reducing agent aqueous solution to the, reactor at a low temperature, to obtain a diepoxide 91% crude, product through 95% a, one-pot reaction, of the diolefin and the m-chloroperoxybenzoic acid solution to obtain a diepoxide crude product solution. (by machine translation)
Design and synthesis of new mitomycin dimers containing a seven-membered cyclic disulfide and a diol linkers
Kim, Jae Jin,Kim, Hyoung Rae,Arai, Hitoshi,Lee, Sang Hyup
, p. 1413 - 1420 (2013/01/15)
We report the design and synthesis of two new mitomycin dimers, 7-N,7′-N′-(1″,2″-dithiepanyl- 3″,7″- dimethylenyl)bismitomycin C (8) and 7-N,7′-N′-(2″,6″- dihydroxy-1″,7″-heptanediyl)bismitomycin C (9). Mitomycins 8 and 9 are dimers connected by a seven-membered cyclic disulfide (a 1,2-dithiepane) and a 2,6-dihydroxyheptane linkers, respectively. Mitomycin 8 was designed to undergo efficient nucleophilic activation and following alkylation to give DNA adducts such as DNA interstrand cross-link (DNA ISC) adducts. The key moiety in 8 is a seven-membered cyclic disulfide linker that can generate two thiol groups in a molecule through disulfide cleavage. The two thiols can serve as probes to activate two mitomycin rings by intramolecular cyclization to quinone rings. The mitomycin 8 was synthesized using mitomycin A (1) and the key intermediate, cyclic disulfide 11 that was prepared through a nine-step synthetic sequence from 1,6- heptadiene (12). The diol mitomycin 9 was also synthesized from 1 and diamine salt 15.
Anti-arrhythmia agents
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, (2008/06/13)
Acetamide derivatives are provided having the structure STR1 wherein X is a single bond, --CH2 -- or --O--, R1 and R2 may be the same or different and are lower alkyl, phenyl-lower alkoxy-lower alkyl, lower alkenyl, phenyl-lower alkyl or lower alkoxy, or STR2 may be taken together to form a 5- to 7-membered heterocyclic ring optionally containing one other hetero atom, such as nitrogen, sulfur or oxygen; Y is hydroxyl, OR wherein R is lower alkyl, lower alkenyl or lower alkanoyl, or STR3 wherein R1 and R2, and R1 and R2 taken together with the nitrogen to which they are attached are as defined above, and n is 1 to 6. These compounds are useful as anti-arrhythmia agents and have been found to be effective in the treatment of acute myocardial infarction.
