3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea, commonly known as N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU), is a potent chemotherapy drug that targets specific types of cancer by disrupting the DNA synthesis and repair mechanisms within cancer cells. As a powerful alkylating agent, BCNU forms covalent bonds with DNA, thereby inhibiting cell division and inducing cell death. Despite its effectiveness, BCNU is associated with several side effects and requires careful administration and monitoring by healthcare professionals.
42471-43-2
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Basic information
- Product Name: 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea
- Synonyms: 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea;N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)urea;Nsc290810;Hydrochloric NiMustine
- CAS NO:42471-43-2
- Molecular Formula: C9H14ClN5O
- Molecular Weight: 243.69
- EINECS: N/A
- Product Categories: N/A
- Mol File: 42471-43-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 523.4°Cat760mmHg
- Flash Point: 270.3°C
- Appearance: /
- Density: 1.307g/cm3
- Vapor Pressure: 4.76E-11mmHg at 25°C
- Refractive Index: 1.583
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea(CAS DataBase Reference)
- NIST Chemistry Reference: 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea(42471-43-2)
- EPA Substance Registry System: 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea(42471-43-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 42471-43-2(Hazardous Substances Data)
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42471-43-2 Usage
Uses
Used in Oncology:3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea is used as a chemotherapeutic agent for the treatment of certain brain tumors, lymphoma, and multiple myeloma. It is effective in targeting and killing cancer cells by interfering with their DNA synthesis and repair processes, leading to cell death.
Used in Cancer Treatment:
In the medical industry, 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea is used as an anticancer drug for the management of various malignancies. Its alkylating properties enable it to form covalent bonds with DNA, preventing cell division and causing the death of cancer cells. However, due to its potential side effects, such as nausea, vomiting, bone marrow suppression, and increased risk of infection, it is typically administered intravenously and requires close monitoring by healthcare professionals.
Check Digit Verification of cas no
The CAS Registry Mumber 42471-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,7 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.Calculate Digit Verification of CAS Registry Number 42471-43:
(7*4)+(6*2)+(5*4)+(4*7)+(3*1)+(2*4)+(1*3)=102
102 % 10 = 2
So 42471-43-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H14ClN5O/c1-6-13-4-7(8(11)15-6)5-14-9(16)12-3-2-10/h4H,2-3,5H2,1H3,(H2,11,13,15)(H2,12,14,16)
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42471-43-2Downstream Products
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3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea
