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CAS

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42473-02-9

2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione is a complex organic compound characterized by the presence of a tetrahydrofuran ring with a carbonyl group at the second position, fused to an isoindole-1,3(2H)-dione moiety. This unique molecular structure endows it with potential biological activity, making it a compound of interest in the field of medicinal chemistry.

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  • 42473-02-9 Structure

  • Basic information

    1. Product Name: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione
    2. Synonyms: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione
    3. CAS NO:42473-02-9
    4. Molecular Formula: C12H9NO4
    5. Molecular Weight: 231.21
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 42473-02-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 448.7°C at 760 mmHg
    3. Flash Point: 225.2°C
    4. Appearance: /
    5. Density: 1.516g/cm3
    6. Vapor Pressure: 3.04E-08mmHg at 25°C
    7. Refractive Index: 1.653
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(42473-02-9)
    12. EPA Substance Registry System: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(42473-02-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 42473-02-9(Hazardous Substances Data)

42473-02-9 Usage

Uses

Used in Medicinal Chemistry:
2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione is used as a compound with potential biological activity for the development of new pharmaceutical agents. Its unique structure may contribute to its interaction with biological targets, offering opportunities for the treatment of various diseases and conditions.
Further research is necessary to fully understand the properties and potential uses of 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione, including its pharmacological profile, safety, and efficacy. This will help to determine its suitability for specific applications in the pharmaceutical industry and guide the development of novel therapeutic agents based on its structure.

Check Digit Verification of cas no

The CAS Registry Mumber 42473-02-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,7 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 42473-02:
(7*4)+(6*2)+(5*4)+(4*7)+(3*3)+(2*0)+(1*2)=99
99 % 10 = 9
So 42473-02-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H9NO4/c14-10-7-3-1-2-4-8(7)11(15)13(10)9-5-6-17-12(9)16/h1-4,9H,5-6H2

42473-02-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-Oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione

1.2 Other means of identification

Product number -
Other names 2-(2-oxooxolan-3-yl)isoindole-1,3-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42473-02-9 SDS

42473-02-9Relevant articles and documents

Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one

Wieckowski, Krzysztof,Bytnar, Justyna,Bajda, Marek,Malawska, Barbara,Salat, Kinga,Filipek, Barbara,Stables, James P.

, p. 6533 - 6544,12 (2012/12/11)

A series of derivatives of dihydrofuran-2(3H)-one (γ-butyrolactone, GBL) was synthesized and tested for anticonvulsant, neurotoxic and analgesic activity. In the anticonvulsant screening 10 lactones were effective in the maximal electroshock test (MES) at the highest doses (300 and 100 mg/kg, 0.5 h, ip, mice). Statistical analysis showed correlation between the anticonvulsant activity and relative lipophilicity parameters determined by experimental and computational methods (RM0, C log P and M log P). Preliminary antinociceptive evaluation of selected derivatives revealed strong analgesic activity. The majority of the tested compounds showed high efficacy in animal models of acute pain (hot plate and writhing tests) and strong local anesthetic activity (modified tail immersion test). The obtained ED50 values were comparable with such analgesics as acetylsalicylic acid and morphine.

Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one

Wi?ckowski, Krzysztof,Sa?at, Kinga,Bytnar, Justyna,Bajda, Marek,Filipek, Barbara,Stables, James P.,Malawska, Barbara

, p. 6533 - 6544 (2013/01/14)

A series of derivatives of dihydrofuran-2(3H)-one (γ-butyrolactone, GBL) was synthesized and tested for anticonvulsant, neurotoxic and analgesic activity. In the anticonvulsant screening 10 lactones were effective in the maximal electroshock test (MES) at the highest doses (300 and 100 mg/kg, 0.5 h, ip, mice). Statistical analysis showed correlation between the anticonvulsant activity and relative lipophilicity parameters determined by experimental and computational methods (RM0, C log P and M log P). Preliminary antinociceptive evaluation of selected derivatives revealed strong analgesic activity. The majority of the tested compounds showed high efficacy in animal models of acute pain (hot plate and writhing tests) and strong local anesthetic activity (modified tail immersion test). The obtained ED50 values were comparable with such analgesics as acetylsalicylic acid and morphine.

FACILE SYNTHESIS OF D,L-PHOSPHINOTHRICIN FROM METHYL 4-BROMO-2-PHTHALIMIDOBUTYRATE

Logusch, E. W.

, p. 5935 - 5938 (2007/10/02)

Synthetic versatility of the title bromide is illustrated by simple preparations of D,L-phosphinothricin, D,L-2-amino-4-phosphonobutyric acid, and aminocyclopropanecarboxylic acid.

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