42478-33-1Relevant academic research and scientific papers
Synthesis and stereochemistry of the epoxides of 2-arylmethylidene-1-tetralones
Adam, Waldemar,Halasz, Judit,Jambor, Zsigmond,Levai, Albert,Nemes, Csaba,Patonay, Tamas,Toth, Gabor
, p. 395 - 400 (1996)
Oxidation of both the E and Z isomers of the 2-arylmethylidene-1-tetralones 1 by alkaline hydrogen peroxide afforded the spiroepoxides trans-2a-g as sole products in high yields. In contrast, the dimethyldioxirane epoxidation of the E isomers 1a-g gave th
Highly enantioselective epoxidation of olefins by H2O2 catalyzed by a non-heme Fe(ii) catalyst of a chiral tetradentate ligand
Mitra, Mainak,Cusso, Olaf,Bhat, Satish S.,Sun, Mingzhe,Cianfanelli, Marco,Costas, Miquel,Nordlander, Ebbe
, p. 6123 - 6131 (2019/05/16)
The chiral tetradentate N4-donor ligand, 1-methyl-2-({(S)-2-[(S)-1-(1-methylbenzimidazol-2-yl methyl)pyrrolidin-2-yl]pyrrolidin-1-yl}methyl) benzimidazole (S,S-PDBzL), based on a chiral dipyrrolidine backbone, has been synthesized and its corresponding Fe(ii) complex has been prepared and characterized. The X-ray structure of the complex reveals that the Fe(ii) ion is in a distorted octahedral coordination environment with two cis-oriented coordination sites occupied by (labile) triflate anions. The ability of the iron complex to catalyze asymmetric epoxidation reactions of olefins with H2O2 was investigated, using 2-cyclohexen-1-one, 2-cyclopenten-1-one, cis-β-methylstyrene, isophorone, chalcones and tetralones as substrates. Different carboxylic acids were used as additives to enhance yields and enantioselectivities, and 2-ethylhexanoic acid was found to give the best results. The catalysis results indicate that the Fe(ii) complex is capable of effecting comparatively high enantioselectivities (>80%) in the epoxidation reactions.
Substituted naphtho pyrazoles
-
, (2008/06/13)
Substituted naphtho [1,2-c] pyrazoles, e.g., 3-(4-pyridyl)-2H-naphtho[1,2-c]-pyrazole, are useful as non-estrogenic anti-fertility agents.
Substituted indeno, naphtho and cyclohepta pyrazoles
-
, (2008/06/13)
Substituted indeno [1,2-c] pyrazoles, naphtho [1,2-c] pyrazoles and benzo [6,7] cyclohepta [1,2-c] pyrazoles e.g., 3-(2,3-dimethoxyphenyl)-4H-indeno[1,2-c] pyrazole and 4,5-dihydro-3-(4-pyridyl)-2H-naphtho[1,2-c] pyrazole, are useful as non-estrogenic anti-fertility agents and antihypertensive agents.
