424789-58-2

Upstream product

• 424789-56-0 ((2S,3S)-3-((2R,3R,4S)-3-(tert-butyl(dimethyl)silyloxy)-4-methylhexan-2-yl)oxiran-2-yl)methanol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 424789-55-9 (4R,5R,6S,E)-methyl 5-(tert-butyl(dimethyl)silyloxy)-4,6-dimethyloct-2-enoate 
• 424789-53-7 (4R,5R,6S,E)-5-(tert-butyl(dimethyl)silyloxy)-4,6-dimethyloct-2-en-1-ol 
• 248251-87-8 (4S)-4-benzyl-3-[(2S,3R,4S)-3-hydroxy-2,4-dimethylhexanoyl]oxazolidin-2-one 
• 206651-87-8 (2S,3R,4S)-3-(tert-butyl(dimethyl)silyloxy)-N-methoxy-N,2,4-trimethylhexanamide 
• 206651-88-9 (2S,3R,4S)-3-[(tert-butyl)dimethylsilyloxy]-2,4-dimethylhexanal 
• 856675-77-9 (2S,3R,4S)-3-hydroxy-N-methoxy-N,2,4-trimethylhexanamide 
• 1730-97-8 (S)-2-methylbutyraldehyde 
• 478800-16-7 [3S,4R,5R,5(2R),5(4R),5(5R)]-5-{2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl}-3-methylhexan-4-ol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 424789-57-1 (2R,3R,4R,5R,6S)-2,4,6-trimethyl-5-(tert-butyldimethylsilanyloxy)octane-1,3-diol 

Downstream Products

• 1027403-42-4 (2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-octanal 
• 424789-61-7 (2R,3R,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-octan-1-ol 

Relevant academic research and scientific papers

Total synthesis of the potent antitumor polyketide (-)-callystatin A

A highly convergent and efficient total synthesis of the potent antitumor polyketide (-)-callystatin A is described. The synthesis required 19 steps from N-propionyl oxazolidinone 23 and produced the desired product in 3.5% overall yield.

Oxabicyclo[3.2.1]oct-6-enes as templates for the stereoselective synthesis of polypropionates: Total synthesis of callystatin a and C19-epi-callystatin A

The total synthesis of the polyketide natural product callystatin A and its novel analog C19-epi-callystatin A is described. Our strategy features the use of an enantiomerically pure oxabicyclo[3.2.1]oct-6-ene as a template for the stereocontrolled preparation of the C15-C21 polypropionate region.

Synthesis of C13-C22 fragment of the marine sponge polyketide callystatin A

We wish to report here our initial efforts towards the total synthesis of callystatin A, describing the synthesis of the C13-C22 fragment. This asymmetric approach uses an efficient syn-aldol reaction, and a diastereoselective epoxidation of an allylic al