424804-32-0Relevant academic research and scientific papers
Polyalkoxybenzenes from plant raw materials 4. Parsley and dill seed extracts in the synthesis of polyalkoxy-3,5-diaryl-1,2,4-oxadiazoles with antiproliferative activity
Konyushkin,Godovikova,Vorontsova,Tsyganov,Karmanova,Raihstat,Firgang,Pokrovskii,Pokrovskii,Semenova,Semenov
, p. 2268 - 2275 (2011/08/05)
Polyalkoxy-5-(4-hydroxyphenyl)-3-phenyl-1,2,4-oxadiazoles were prepared from allylpolyalkoxybenzenes, the main metabolites of parsley and dill seeds. Due to the spatial arrangement of the aryl substituents provided by 1,2,4-oxadiozole fragment, these compounds can be considered as structural analogs of natural antimitotic combretastatins. The antimitotic activity of the synthesized compounds was evaluated in vivo using sea urchin embryo test.
