424813-73-0Relevant academic research and scientific papers
A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles
McAllister, Laura A.,McCormick, Rosemary A.,James, Karen M.,Brand, Stephen,Willetts, Nigel,Procter, David J.
, p. 1032 - 1046 (2007)
A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles.
