42482-72-4Relevant academic research and scientific papers
Cytotoxic and Apoptosis-inducing Activities of Taraxastane-type Triterpenoid Derivatives in Human Cancer Cell Lines
Ukiya, Motohiko,Ohkubo, Chika,Kurita, Masahiro,Fukatsu, Makoto,Suzuki, Takashi,Akihisa, Toshihiro
, p. 1018 - 1029 (2016/09/12)
Twenty-eight taraxastane-type triterpenoid derivatives 4?–?31 were prepared from the naturally occurring triterpenoids faradiol (1) and heliantriol C (3). The cytotoxic activities of these compounds and arnidiol (2) were evaluated in leukemia (HL60), lung (A549), duodenal (AZ521), and breast (SK-BR-3) cancer cell lines. 21-Oxoarnidiol (18) and faradiol 3,16-di-O-l-alaninate (31) exhibited potent cytotoxicity, with 50% inhibitory concentrations of 0.5?–?2.7?μm. In particular, flow cytometric analysis indicated that compound 31 induced typical apoptotic cell death in HL60 cells. These results suggested that taraxastane-type triterpenoid derivatives might provide useful antitumor agents with apoptosis-inducing activity.
