424828-97-7Relevant articles and documents
Total synthesis of (+)-amphidinolide A. Structure elucidation and completion of the synthesis
Trost, Barry M.,Harrington, Paul E.,Chisholm, John D.,Wrobleski, Stephen T.
, p. 13598 - 13610 (2007/10/03)
The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis and total synthesis. The 20-membered ring of amphidinolide A was formed by a ruthenium-catalyzed alken
Ruthenium-catalyzed alkene-alkyne coupling: Synthesis of the proposed structure of amphidinolide A
Trost, Barry M.,Chisholm, John D.,Wrobleski, Stephen T.,Jung, Michael
, p. 12420 - 12421 (2007/10/03)
The ruthenium-catalyzed alkene-alkyne coupling provides a powerful method for the synthesis of 1,4 dienes and a way to simplify synthetic strategy. The latter potential is explored in the context of a synthesis of the assigned structure of amphidinolide A