424834-59-3 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole-5-carboxaldehyde,7-fluoro-(9CI) is used as a building block in organic synthesis for the development of new pharmaceuticals. Its unique structure and reactivity allow for the creation of compounds with potential therapeutic applications, particularly in the areas of antimicrobial and anticancer treatments.
Used in Agrochemical Industry:
In the agrochemical field, 1H-Indole-5-carboxaldehyde,7-fluoro-(9CI) is utilized as a precursor in the synthesis of agrochemicals. Its properties can be harnessed to develop new compounds with pesticidal or herbicidal activities, contributing to more effective crop protection strategies.
Used in Materials Science:
1H-Indole-5-carboxaldehyde,7-fluoro-(9CI) is also employed in materials science for the development of novel materials with specific properties. Its chemical reactivity and structural characteristics can be leveraged to create materials with applications in various industries, such as electronics or nanotechnology.
Overall, 1H-Indole-5-carboxaldehyde,7-fluoro-(9CI) is a versatile chemical compound with a wide range of applications across different industries, primarily due to its unique structure and potential for use in the synthesis of new and effective compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 424834-59-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,4,8,3 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 424834-59:
(8*4)+(7*2)+(6*4)+(5*8)+(4*3)+(3*4)+(2*5)+(1*9)=153
153 % 10 = 3
So 424834-59-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6FNO/c10-8-4-6(5-12)3-7-1-2-11-9(7)8/h1-5,11H
424834-59-3Relevant academic research and scientific papers
Potent, orally active heterocycle-based combretastatin A-4 analogues: Synthesis, structure - Activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation
Wang, Le,Woods, Keith W.,Li, Qun,Barr, Kenneth J.,McCroskey, Richard W.,Hannick, Steven M.,Gherke, Laura,Credo, R. Bruce,Hui, Yu-Hua,Marsh, Kennan,Warner, Robert,Lee, Jang Y.,Zielinski-Mozng, Nicolette,Frost, David,Rosenberg, Saul H.,Sham, Hing L.
, p. 1697 - 1711 (2007/10/03)
The synthesis and structure - activity relationship study of a series of compounds with heterocycles in place of the cis double bond in combretastatin A-4 (CA-4) are described. Substituted tosylmethyl isocyanides were found to be the key intermediates in construction of the heterocycles. Cytotoxicities of the heterocycle-based CA-4 analogues were evaluated against NCI-H460 and HCT-15 cancer cell lines. 3-Amino-4-methoxyphenyl and N-methyl-indol-5-yl were the best replacements for the 3-hydroxy-4-methoxyphenyl in CA-4. 4,5-Disubstituted imidazole was found to be the best for the replacement of the cis double bond in CA-4. Medicinal chemistry efforts led to the discovery of compounds 24h and 25f that were found to be 32 and 82% bioavailable, respectively, in rat. Evaluation of 24h and 25f against murine M5076 reticulum sarcoma in mice revealed that both compounds were orally efficacious with an increase in life span of 38.5 and 40.5%, respectively.
