42501-87-1

Upstream product

• 104-94-9 4-methoxy-aniline 
• 446-52-6 2-Fluorobenzaldehyde 
• 89-99-6 2-fluorobenzylamine 

Downstream Products

• 1133378-62-7 (2S,3S)-2-(2-fluorophenyl)-1-(4-methoxyphenyl)-1,2,3,4-tetrahydropyridine-3-carbaldehyde 
• 3295-60-1 2-methoxyacridine 
• 1512859-13-0 C₂₁H₂₀N₂O₂ 
• 1440008-56-9 ((2S,3S)-2-(2-fluorophenyl)-1-(4-methoxyphenyl)piperidin-3-yl)methanol 
• 1381866-30-3 4-(2-(2-fluorophenyl)-6-methoxy-3-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol 
• 1384176-02-6 ((2S,3S)-2-(2-fluorophenyl)-1-(4-methoxyphenyl)pyrrolidin-3-yl)methanol 

Relevant academic research and scientific papers

Synthesis, structures, photoluminescent and electroluminescent properties of boron complexes with anilido-imine ligands

Syntheses of three new N-arylanilido-arylimine bidentate Schiff base type ligand precursors, ortho-C6H4[NH(2,6-iPr2C6H3)](CH{double bond, long}NAr1) [Ar1 = p-FC6

Unsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its iridium complex supported on hydrotalcite was characterized via X-ray power diffraction (XRD), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray (EDX) spectroscopy and transmission electron microscopy (TEM). This new heterogeneous catalyst bearing the unsymmetrical indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in water. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, it was observed that this catalyst system showed good recovery performance in water. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Paclitaxel Biosynthesis: Adenylation and Thiolation Domains of an NRPS TycA PheAT Module Produce Various Arylisoserine CoA Thioesters

Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical

Enantioselective synthesis of 1,2,5,6-tetrahydropyridines (THPs): Via proline-catalyzed direct Mannich-cyclization/domino oxidation-reduction sequence: Application for medicinally important N-heterocycles

An enantioselective multi-component synthesis of 1,2,5,6-tetrahydropyridines (THPs) has been developed through a one-pot domino-process. This transformation proceeds through proline-catalyzed direct Mannich reaction-cyclization of glutaraldehyde with in s

Ir-Catalyzed C?H Amidation of Aldehydes with Stoichiometric/Catalytic Directing Group

Ir-catalyzed sp2C?H amidation of aldehydes with various anilines as stoichiometric or catalytic directing groups was accomplished. A wide range of substrates were selectively amidated in good to excellent yields with broad functional group tolerance. The iridacycle complexes were isolated, characterized, and proved as key intermediates. Kinetic studies and Hammett plots provided detailed understandings of this amidation. According to the mechanism, the electron-rich ArSO2N3was proved effective for intermolecular sp3C?H amidation.

Facile synthesis of acridine derivatives by ZnCl2-promoted intramolecular cyclization of o -arylaminophenyl schiff bases

A concise and efficient method for the synthesis of a wide range of acridine derivatives and polycyclic aza-aromatic compounds from a ZnCl 2-promoted cyclization reaction of readily available o-arylaminophenyl Schiff base compounds under convenient conditions was developed. Reaction conditions and scope of the new method were examined in detail.

Chiral phosphoric acid catalyzed inverse-electron-demand aza-Diels-Alder reaction of isoeugenol derivatives

Highly enantio- and diastereoselective three-component inverse electron-demand aza-Diels-Alder reaction of aldehydes, anilines, and isoeugenol derivatives catalyzed by a chiral phosphoric acid catalyst are reported. A wide variety of 2,3,4-trisubstituted tetrahydroquinolines containing an aryl group at the 4-position were obtained in a one-pot process with good to high yields and excellent stereoselectivities (>95:5 dr and up to >99% ee).

Proline-mediated enantioselective construction of tetrahydropyridines via a cascade Mannich-type/intramolecular cyclization reaction

A highly diastereo- and enantioselective synthesis of 2,3-disubstituted tetrahydropyridines was accomplished via a proline-mediated cascade Mannich-type/intramolecular cyclization reaction from preformed N-PMP (p-methoxyphenyl) aldimines and inexpensive aqueous tetrahydro-2H-pyran-2,6- diol.

Nickel-catalyzed multi-component connection reaction of isoprene, aldimines (lactamines), and diphenylzinc

Ni(acac)2 catalyzes the four-component connection reaction of diphenylzinc, isoprene, aromatic aldehydes, and aromatic amines in this order and provides stereochemically homogeneous (E)-1-arylamino-1-aryl-3-methyl-5-phenyl-3-pentenes (1) in excellent yields. Aliphatic aldehydes react similarly and give (E)-1-arylamino-1-alkyl-3-methyl-5-phenyl-3-pentenes (1) in slightly reduced yields. When the alkyl groups are bulky, in addition to 1 are formed (E)-1-arylamino-1-alkyl-4-methyl-5-phenyl-3-pentenes (1′) as the minor products. Lactamines prepared in situ from five- and six-membered lactols and aromatic amines are more reactive than alkyl aldehyde aldimines and furnish (E)-4-arylamino-6-methyl-8-phenyl-6-octen-1-ols (4) and (E)-5-arylamino-7-methyl-9- phenyl-7-nonen-1-ols (5), respectively, in good yields with excellent E-stereoselectivity.

Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: Stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines

Ni(acac)2 catalyzes the four-component connection reaction of trimethylaluminium (or diphenylzinc), isoprene, aromatic aldehydes and p-anisidine in this order and provides (E)-1-aryl-1-(p-methoxyphenyl)amino-3- methyl-3-hexenes (or (E)-1-aryl-1