42508-82-7Relevant articles and documents
Synthesis and structure of flavan-4-ols and 4-methoxyflavans as new potential anticancer drugs
Pouget, Christelle,Fagnere, Catherine,Basly, Jean-Philippe,Leveque, Hubert,Chulia, Albert-José
, p. 6047 - 6052 (2007/10/03)
Reduction of a series of substituted flavanones afforded synthetic access to flavan-4-ols and was followed for some of them by an S(N)2-type acid-catalysis in methanol to provide 4-methoxyflavans. The stereochemistry of these compounds was established by 1H and 13C NMR data. Flavan-4-ols and 4-methoxyflavans have been resolved into enantiomers which are being evaluated as anticancer drugs. (C) 2000 Elsevier Science Ltd.