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3,5-diiodo-4-methoxybenzoic acid is an organic compound with the chemical formula C8H6I2O3. It is a derivative of benzoic acid, featuring two iodine atoms at the 3rd and 5th positions, and a methoxy group at the 4th position. 3,5-diiodo-4-methoxybenzoic acid is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as an intermediate in the production of certain drugs and pesticides. It is characterized by its ability to undergo various chemical reactions due to the presence of the iodine atoms, which can be substituted or used in cross-coupling reactions. The compound is typically obtained through multi-step synthetic processes, and its properties, such as solubility and reactivity, are influenced by the electron-withdrawing nature of the iodine atoms and the electron-donating effect of the methoxy group.

4253-11-6

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4253-11-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4253-11-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,5 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4253-11:
(6*4)+(5*2)+(4*5)+(3*3)+(2*1)+(1*1)=66
66 % 10 = 6
So 4253-11-6 is a valid CAS Registry Number.

4253-11-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,5-diiodo-4-methoxybenzoic acid

1.2 Other means of identification

Product number -
Other names Benzoic acid,3,5-diiodo-4-methoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4253-11-6 SDS

4253-11-6Relevant academic research and scientific papers

Accurate tuning of rare earth metal-organic frameworks with unprecedented topology for white-light emission

Wang, Yutong,Zhang, Kai,Wang, Xiaokang,Xin, Xuelian,Zhang, Xiurong,Fan, Weidong,Xu, Ben,Dai, Fangna,Sun, Daofeng

supporting information, p. 1374 - 1379 (2020/02/11)

A series of isostructural rare-earth metal-organic frameworks (RE-MOFs), namely {[RE(L-X)(H2O)]·2DMF}n (UPC-38, RE = Eu, Tb, X = H, F, Cl, NH2, CH3, OCH3; L = [1,1′:3′,1′′-terphenyl]-4,4′′,5′-tricarbo

Optimizing Multivariate Metal-Organic Frameworks for Efficient C2H2/CO2Separation

Fan, Weidong,Yuan, Shuai,Wang, Wenjing,Feng, Liang,Liu, Xiuping,Zhang, Xiurong,Wang, Xia,Kang, Zixi,Dai, Fangna,Yuan, Daqiang,Sun, Daofeng,Zhou, Hong-Cai

supporting information, p. 8728 - 8737 (2020/12/25)

Adsorptive separation of acetylene (C2H2) from carbon dioxide (CO2) promises a practical way to produce high-purity C2H2 required for industrial applications. However, challenges exist in the pore environment engineering of porous materials to recognize two molecules due to their similar molecular sizes and physical properties. Herein, we report a strategy to optimize pore environments of multivariate metal-organic frameworks (MOFs) for efficient C2H2/CO2 separation by tuning metal components, functionalized linkers, and terminal ligands. The optimized material UPC-200(Al)-F-BIM, constructed from Al3+ clusters, fluorine-functionalized organic linkers, and benzimidazole terminal ligands, demonstrated the highest separation efficiency (C2H2/CO2 uptake ratio of 2.6) and highest C2H2 productivity among UPC-200 systems. Experimental and computational studies revealed the contribution of small pore size and polar functional groups on the C2H2/CO2 selectivity and indicated the practical C2H2/CO2 separation of UPC-200(Al)-F-BIM.

Topology Exploration in Highly Connected Rare-Earth Metal-Organic Frameworks via Continuous Hindrance Control

Wang, Yutong,Feng, Liang,Fan, Weidong,Wang, Kun-Yu,Wang, Xia,Wang, Xiaokang,Zhang, Kai,Zhang, Xiurong,Dai, Fangna,Sun, Daofeng,Zhou, Hong-Cai

supporting information, p. 6967 - 6975 (2019/05/10)

The structural diversity of highly connected metal-organic frameworks (MOFs) has long been limited due to the scarcity of highly connected metal clusters and the corresponding available topology. Herein, we deliberately chose a series of tritopic linkers

Topology Exploration in Highly Connected Rare-Earth Metal-Organic Frameworks via Continuous Hindrance Control

Wang, Yutong,Feng, Liang,Fan, Weidong,Wang, Kun-Yu,Wang, Xia,Wang, Xiaokang,Zhang, Kai,Zhang, Xiurong,Dai, Fangna,Sun, Daofeng,Zhou, Hong-Cai

supporting information, (2019/05/06)

The structural diversity of highly connected metal-organic frameworks (MOFs) has long been limited due to the scarcity of highly connected metal clusters and the corresponding available topology. Herein, we deliberately chose a series of tritopic linkers

Oxidative iodination of deactivated arenes in concentrated sulfuric acid with I2/NaIO4 and KI/NaIO4 iodinating systems

Kraszkiewicz, Lukasz,Sosnowski, Maciej,Skulski, Lech

, p. 1195 - 1199 (2007/10/03)

Deactivated arenes were mono- or diiodinated with strong electrophilic I+ reagents, which were prepared from NaIO4 and either I2 or KI in concentrated H2SO4 (minimum 95% by weight). In general a small excess of the dark brown iodinating solution was used (1.1/1.5 equivalents, for nitrobenzene two equivalents was required). The iodinations were conducted at 25-30 °C with a reaction time of 1-2 hours using either a 'direct' or an 'inverse' method of aromatic iodination to give mono- or diiodinated pure products in 31-91% optimized yields. Georg Thieme Verlag Stuttgart.

Easy, inexpensive and effective oxidative iodination of deactivated arenes in sulfuric acid

Kraszkiewicz, Lukasz,Sosnowski, MacIej,Skulski, Lech

, p. 9113 - 9119 (2007/10/03)

Two 'model' deactivated arenes, benzoic acid and nitrobenzene, were effectively monoiodinated within 1 h at 25-30 °C, with strongly electrophilic I+ reagents, prior prepared from diiodine and various oxidants (CrO3, KMnO4, active MnO2, HIO 3, NaIO3, or NaIO4) in 90% (v/v) concd sulfuric acid (ca. 75 mol% H2SO4). Next, an I2/ NaIO3/90% (v/v) concd H2SO4 exemplary system was used to effectively mono- or diiodinate a number of deactivated arenes. All former papers dealing with the direct iodination of deactivated arenes are briefly reviewed.

Steric Enhancement of Resonance-Evidence from Kinetic Study on some Acetophenones

Pillay, M. Krishna,Palanivelu, S.

, p. 1055 - 1059 (2007/10/02)

The kinetics of oxidation of some mono-, di- and tri-substituted acetophenones by alkaline hexacyanoferrate(III) in 50percent (v/v) methanol-water mixture at constant ionic strength and at 20, 30 and 40 deg have been studied spectrophotometrically and the rate constants determined by least-squares analysis.Electron-withdrawing groups in the ring facilitate the oxidation of the acetyl function while electron-releasing groups retard the rate.The rate constant values for the oxidation of 3-substituted-4-alkoxy-acetophenones are computed based on the principle of additivity of group effects.The observed rate constants are significantly lower than the calculated values.This is attributed to the phenomenon of steric enhancement of resonance (SER). 3,5-Disubstituted-4-methoxyacetophenones have higher observed rate constant values than the calculated ones.The steric inhibition of resonance (SIR) operates in these systems.In the case of 3-halogeno-4-methoxyacetophenones, the importance of SER increases with increase in the bulkiness of the 3-substituents.The difference between the calculated and observed multiple substituent constants of 3-substituted-4-methoxyacetophenones also lends support for SER.

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