4253-64-9Relevant academic research and scientific papers
EXTRAHEPATIC DELIVERY
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, (2021/05/15)
One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.
TRANSTHYRETIN (TTR) IRNA COMPOSITION AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES
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, (2021/05/15)
The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR- associated ocular diseases.
ESTER FORMATION OF FATTY ACID AND HYDROXYCARBOXYLIC AID
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Page/Page column 8, (2014/01/09)
The present invention relates to a process for the transesterification of a fatty acid ester of a lower alcohol and a salt of hydroxycarboxylic acid without making use of organic solvents. The process can also be carried out without added anionic surface active agents.
NMR and HPLC characterisation of O-alkanoyl lactates prepared by lipase catalysis
Kiran,Divakar
, p. 1686 - 1693 (2007/10/03)
Lactic acid esters of organic acids like lauroyl, palmitoyl and stearoyl lactic acids prepared by using lipases have been characterized by 1H and 13C NMR spectra. The reaction mixture indicates the presence of several species due to complex esterification equilibria. Crystalline lactic acid employed for reactions shows more lactylate content than the commercially available lactic acid. The -CH-O- region between 4.03 and 5.13 ppm gives quite a lot of information on the ester formation as this region contains signals from free lactic acid, hydroxyl terminal group of lactylates, carboxyl terminal group of lactylates and lactic acid and lactylate esters of organic acids employed. The ester yields determined by HPLC and NMR are comparable and are less than those determined by titration method.
