425392-76-3

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structural features, including bromine, chlorine, and trifluoromethyl groups, contribute to the enhancement of biological activity and potency of the resulting drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BROMO-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE is utilized as a building block for the synthesis of novel agrochemicals. Its reactivity and structural diversity allow for the creation of more effective and targeted pesticides and other agricultural chemicals.
Used in Fine Chemicals Industry:
5-BROMO-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE is employed as a versatile intermediate in the synthesis of fine chemicals, including specialty chemicals and advanced materials. Its high reactivity and the presence of multiple functional groups make it suitable for various applications in this industry.
Used in Organic Synthesis:
As a key component in organic synthesis, 5-BROMO-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE is used for the preparation of a wide range of organic compounds. Its unique structural features and reactivity enable the synthesis of complex molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-BROMO-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE is utilized for the design and synthesis of new drug candidates. Its structural diversity and reactivity allow for the development of compounds with improved biological activity and therapeutic potential.

InChI:InChI=1/C5HBrClF3N2/c6-2-3(5(8,9)10)11-1-12-4(2)7/h1H

Upstream product

• 126538-81-6 5-bromo-4-trifluoromethyl-pyrimidin-6-one 

Downstream Products

• 447402-02-0 5-bromo-4-methoxy-6-trifluoromethyl-pyrimidine 

Relevant academic research and scientific papers

Intramolecular Metal-Free N?N Bond Formation with Heteroaromatic Amines: Mild Access to Fused-Triazapentalene Derivatives

Formation of N?N bonds may offer an original approach to various nitrogen-containing heterocycles with numerous applications. For this purpose, we found that readily available heteroaromatic amines are appropriate substrates for providing an efficient and innovative approach for the formation of N?N bonds in the presence of iodine (III) reagent in very mild conditions. This method makes it possible to synthesize nitrogen rich triazapentalene derivatives exhibiting fluorescent properties, inaccessible with existing approaches.

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

NOVEL HERBICIDES

Compounds of formula I: wherein R1, R2, R3, R4, m, R5, R6, n and Y are as defined in claim 1; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to herbicidal compositions comprising them and to methods of using them to control plants or to inhibit plant growth.

Metal-bearing and trifluoromethyl-substituted pyrimidines: Generation and functionalization

5-Pyrimidyllithium species are fairly stable when the metal is flanked by two electron-withdrawing substituents such as trifluoromethyl and chlorine or bromine. Thus, the corresponding 5-carboxylic acids are produced in high yields from 4,5-dibromo-6-(trifluoromethyl)pyrimidine and 5-bromo-4-chloro-6- (trifluoromethyl)pyrimidine upon halogen/metal permutation accomplished with isopropylmagnesium chloride or butyllithium followed by carboxylation. Satisfactory or excellent yields of 5-carboxylic acids are equally obtained when 4-chloro-, 2,4-dichloro- and 2,4-dibromo-6-(trifluoromethyl)pyrimidine are deprotonated with lithium diisopropylamide before being allowed to react with dry ice. In contrast, consecutive treatment of 2-bromo-4-(trifluoromethyl) pyrimidine and 2-chloro-5-iodo-4-(trifluoromethyl)pyrimidine with butyllithium affords the expected carboxylic acids in only poor yields and not even trace amounts of acid were detected when 4-bromo-6-(trifluoromethyl)pyrimidine served as the substrate. The formation of bipyrimidines, emerging from either one of two competing mechanistic pathways, is a permanently menacing side reaction. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Herbicide compositions

A herbicidal composition which comprises i) an isoxazoline derivative represented by the following general formula (I) or its salt and ii) at least one compound selected from the Group A: Formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined in the specification.

ISOXAZOLINE DERIVATIVES AND HERBICIDES

The present invention aims at providing an isoxazoline derivative and a pharmaceutically acceptable salt thereof, both having an excellent herbicidal effect and an excellent selectivity between crop and weed. The isoxazoline derivative of the present invention is represented by the following general formula: wherein R1 is a haloalkyl group; R2 is a hydrogen atom, an alkyl group, or the like; R3, R4, R5 and R6 are each a hydrogen atom, or the like; Y is a pyrrolyl group, a pyrazolyl group, an isothiazolyl group, an oxazolyl group, an imidazolyl group, a pyridazinyl group, a pyrimidinyl group, a pyrazinyl group, a triazinyl group, a triazolyl group, an oxadiazolyl group, or the like; and n is an integer of 0 to 2.

ISOXAZOLINE DERIVATIVE AND HERBICIDE COMPRISING THE SAME AS ACTIVE INGREDIENT

An isoxazoline derivative represented by the following general formula [I]: wherein R1 and R2 may be the same or different and are each an alkyl group; ???R3, R4, R5 and R6 are each a hydrogen atom; ???Y is an optionally substituted 5- to 6-membered aromatic heterocyclic group or fused aromatic heterocyclic group having a hetero atom selected from a nitrogen atom, a oxygen atom and a sulfur atom; and ???n is an integer of 0 to 2. The isoxazoline derivative has an excellent herbicidal effect and an excellent selectivity between crop and weed.

PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME

The present invention provides a pyrimidine derivative represented by the formula: wherein R1p and R1q are the same or different, and each represents (1)hydrogen, (2)halogen, (3) a C1-6alkyl group which may be substituted or (4) a C1-6alkoxy group, and so on, R2 is halogen, a C1-6alkyl group, cyano group, and so on, Ar is a phenyl group which may be substituted or is a condensed hetero ring which may be substituted, which has excellent selective herbicidal activity, and a herbicide containing the derivative.