425400-77-7

Upstream product

• 672-65-1 (1-chloroethyl)benzene 

Downstream Products

• 118355-06-9 C₁₆H₁₈N₃OP 
• 425407-73-4 (S,S)-bis(α-methylbenzyl)phosphinic chloride 
• 425400-69-7 C₁₆H₁₈ClOP 
• 118355-11-6 (S,S)-bis(α-methylbenzyl)phosphinic acid 
• 118355-10-5 C₂₅H₂₈NO₃P 
• 118355-08-1 C₂₄H₂₈NOP 
• 118355-09-2 Bis-((R)-1-phenyl-ethyl)-phosphinic acid 
• 118396-74-0 ((S)-1-Phenyl-ethyl)-((R)-1-phenyl-ethyl)-phosphinic acid 

Relevant academic research and scientific papers

The Stereochemical Course of Migration from Phosphorus to Nitrogen in the Photo-Curtius Rearrangement of Phosphinic Azides (Harger Reaction)

The homochiral phosphinic azides (R,R)-1 and (S,S)-1 have been prepared in enantiomerically pure form by resolution of diastereomeric phosphinamides derived from (S)-1-phenylethylamine and (R)-phenylglycine.Irradiation of the azides in methanol induced a photo-Curtius rearrangement of phosphonamidates in which the stereogenic carbon unit migrated to a nitrogen atom.Hydrolysis of the phosphonamidates produced 1-phenylethylamine, which was 99.0percent ee and of the same configuration as the carbon unit in the starting azide (99.0percent net retention).The implication for asymmetric synthetic methodology is discussed.