425409-14-9

Upstream product

• 370103-87-0 (1S,1'S)-1,1'-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(but-3-en-1-ol) 
• 37031-29-1 (-)-dimethy-2,3-O-isopropylidene-L-tartrate 
• 63699-97-8 1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol 
• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 129414-16-0 (4R,5R,6R,7R)-5,6-O-methylethylidene-deca-1,9-diene-4,5,6,7-tetrol 
• 425409-13-8 (4S,5R,6R,7S)-5,6-O-methylethylidene-deca-1,9-diene-4,5,6,7-tetrol 

Relevant academic research and scientific papers

Efficient route to optically pure polyfunctionalized cyclooctanes

A short and efficient synthesis of enantiopure highly functionalized eight-membered carbocyclic rings is described from 1,2:5,6-bis-epoxides issued from d-mannitol. The key cyclization step involves the metathesis of 1,9-diene using Grubbs' catalyst or the pinacolic coupling of 1,8-dialdehyde resulting from the oxidative cleavage of the previous diene. In the specific case of ring-closing metathesis cyclization, the influence of a conformationally restricted diene compared to that of a flexible one has been evaluated.

INKT CELL MODULATORS AND METHODS OF USING THE SAME

Disclosed herein are α-galactosylceramide (α-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combinat

Synthesis and glycosidase inhibitory activity of new penta-substituted C8-glycomimetics

The syntheses of new C8-carbasugars and -aminocyclitols related to miglitol and voglibose are described. The key step involves the ring closing metathesis of 1,9-dienes derived from d-mannitol. Chemical transformations of the newly created double bond of the resulting cyclooctenes involved notably hydroboration and reductive amination. The inhibitory activity of the glycomimetics so-obtained has been evaluated towards 24 commercially available glycosidases.