42543-50-0

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 14918-21-9 5-hexynonitrile 
• 217087-88-2 N-methoxy-N-methylhex-5-ynamide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 42543-76-0 1-(4-methoxy-phenyl)-2-morpholin-4-ylmethyl-hex-5-yn-1-one 
• 42543-62-4 1-(4-Methoxy-phenyl)-hex-5-yn-1-ol 
• 42543-56-6 1-(4-methoxyphenyl)-1,5-hexanedione 

Relevant academic research and scientific papers

Room Temperature Allenation of Terminal Alkynes with Aldehydes

A gold-catalyzed room temperature allenation of terminal alkynes (ATA) with aldehydes affording 1,3-disubstituted allenes with diverse functional groups has been developed by identifying a gold(I) catalyst and an amine. The practicality of this reaction has been demonstrated by a ten gram-scale synthesis and the synthetic potentials have been demonstrated via various transformations and formal total synthesis of (?)-centrolobine. Mechanistic studies revealed that the gold catalyst, the aldehyde effect, the fluoroalkyl hydroxyl solvent (TFE or HFIP) and the structure of amine are vital in this room temperature ATA reaction.

Process for the preparation of certain substituted aromatic compounds

The present invention involves process for the preparation of compounds having the chemical structure: STR1 wherein Ar--H is an aromatic compound which is activated to an electrophilic attack, and wherein --Y is an aliphatic group having a labile moiety,