425430-38-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 42248-31-7 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde 

Downstream Products

• 1020671-81-1 C₂₅H₁₇ClF₃NO₄ 

Relevant academic research and scientific papers

Simple and ecofriendly synthesis of dihydropyrimidinones (thiones), dihydropyridines, and pyridines using 3-formylchromones as substrates assisted by a recyclable Preyssler heteropolyacid

Several dihydropyrimidinones/thiones, 1,4-dihydropyridines, and pyridine derivatives were prepared in very good yields and purity values. The corresponding reactions were carried out by employing a bulk Preyssler heteropolyacid H14[NaP5/s

Solvent-free synthesis of functionalized pyridine derivatives using Wells-Dawson heteropolyacid as catalyst

Wells-Dawson heteropolyacids (H6P2W 18O62·24H2O) were used as catalysts in the Hantzsch-like multicomponent condensation reaction with 3-formylchromones as aldehyde component, a β-ketoester and ammonium acetate, under solvent-free conditions at 80 °C. Although the desired products were obtained, functionalized pyridines were the main reaction product and became the alternative route to dihydropyridine ring formation. Based on the proposed mechanisms for the formation of each of the obtained products, the multicomponent reaction was modified to afford only the functionalized pyridines (60-99%). Our procedure represents a clean alternative for the synthesis of several highly functionalized pyridines.

Benzopyrans. Part 42 [1]. Reactions of 4-oxo-4H-1-benzopyran-3-carbaldehyde with some active methylene compounds in the presence of ammonia

The title aldehyde 1 in the presence of ammonia gives the pyridine derivatives 9-11 respectively with acetylacetone, diethyl malonate and ethyl cyanoacetate, and ethyl (or methyl)-1-benzopyrano[4,3-b]pyridine-3-carboxylate 22 (or 23) with ethyl (or methyl