42546-55-4Relevant academic research and scientific papers
Synthesis, crystal structure, and biological evaluation of a series of phloretin derivatives
Wang, Li,Li, Zheng-Wei,Zhang, Wei,Xu, Rui,Gao, Fei,Liu, Yang-Feng,Li, Ya-Jun
, p. 16447 - 16457 (2014/12/12)
A one-step synthesis of phloretin derivatives 2-11 from phloretin in good to excellent yields is reported. Their structures were characterized by 1H-NMR, 13C-NMR and MS, and the structures of 8 and 11 were determined by X-ray diffrac
Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans
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, (2008/06/13)
The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
Inhibitors of intestinal apical membrane na/phoshate co-transportation
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, (2008/06/13)
The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
