425604-48-4

Upstream product

• 18621-06-2 N-trityl-L-tyrosine methyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 76-83-5 trityl chloride 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 613223-79-3 [2-[3-bromo-4-(tert-butyldiphenylsilyloxy)phenyl]-1-(tert-butyldiphenylsilyloxymethyl)ethyl]tritylamine 
• 1315476-19-7 C₂₆H₂₁BrN₆O₄S 
• 1315476-18-6 C₃₃H₂₆BrN₃O₆S 
• 425620-74-2 C₃₂H₃₆BrN₃O₅SSi 
• 425621-30-3 C₂₆H₂₂BrN₃O₅S 
• 425620-77-5 C₂₆H₂₂BrN₃O₅S 
• 613223-76-0 7-[2-(3-bromo-4-tert-butyldiphenylsilyloxyphenyl)-1-(tert-butyldimethylsilyloxymethyl)ethylamino]-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 613223-75-9 7-[2-(3-bromo-4-triisopropylsilyloxyphenyl)-1-(tert-butyldimethylsilyloxymethyl)ethylamino]-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 613223-72-6 7-[2-(3-bromo-4-hydroxyphenyl)-1-(tert-butyldiphenylsilyloxymethyl)ethylamino]-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 590385-88-9 7-[2-(3-bromo-4-tert-butyldimethylsilyloxyphenyl)-1-(tert-butyldimethylsilyloxymethyl)ethylamino]-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 613223-70-4 7-[2-(3-bromo-4-hydroxyphenyl)-1-(triisopropylsilyloxymethyl)ethylamino]-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 590385-69-6 5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-(tert-butyldimethylsilyloxymethyl)-10-spiro-4'-(2'-bromo)-cyclohexa-2',5'-dien-1'-one 
• 613223-81-7 5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-(tert-butyldimethylsilyloxymethyl)-10-spiro-4'-(2'-bromo)-cyclohexa-2',5'-dien-1'-one 
• 613223-73-7 [2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldiphenylsilyloxymethyl)ethyl]tritylamine 

Relevant academic research and scientific papers

Synthetic studies on the sulfur-cross-linked core of antitumor marine alkaloid, discorhabdins: Total synthesis of discorhabdin A

A concise and efficient method to construct the characteristic sulfur-cross-linked core of an unprecedented antitumor marine alkaloid, discorhabdins, has been developed. By utilizing this methodology the first total synthesis of (±)-discorhabdin A (1) has

The synthetic and biological studies of discorhabdins and related compounds

Various analogues of the marine alkaloids, discorhabdins, have been synthesized. The strategy contains spirocyclization with phenyliodine(iii) bis(trifluoroacetate) (PIFA), oxidative fragmentation of the β-amino alcohols with the hypervalent iodine reagent C6F 5I(OCOCF3)2, the detosylation and dehydrogenation reaction of the pyrroloiminoquinone unit in the presence of a catalytic amount of NaN3 and the bridged ether synthesis with HBr-AcOH as the key reactions. All the synthesized compounds were evaluated by in vitro MTT assay for cytotoxic activity against the human colon cancer cell line HCT-116. Furthermore, the discorhabdin A oxa analogues were also evaluated against four kinds of tumor model cells, a human colon cancer cell line (WiDr), a human prostate cancer cell line (DU-145) and murine leukemia cell lines (P388 and L1210). For the identification of the target, discorhabdin A and the discorhabdin A oxa analogue were evaluated by an HCC panel assay. In the test, discorhabdins could have a novel mode of action with the tumor cells. The Royal Society of Chemistry 2011.

Synthesis of antitumor marine alkaloid discorhabdin a oxa analogues

Dlscorhabdin A (1) exhibits a strong cytotoxic activity in vitro, but it Is difficult to synthesize and handle due to the Instability of Its highly strained N.S-acetal structure. We then designed the analogues of discorhabdin A which also have strong cyto

The first total synthesis of discorhabdin A

The first stereoselective total synthesis of a potent antitumor alkaloid, discorhabdin A (1), which is a unique sulfur-containing pyrroloiminoquinone alkaloid, is described. The key step in the stereocontrolled total synthesis of 1 involves both a diaster