42565-85-5Relevant academic research and scientific papers
2,5-Diaryl-1,3,4-oxadiazoles as selective COX-2 inhibitors and anti-inflammatory agents
Grover, Jagdeep,Bhatt, Nirav,Kumar, Vivek,Patel, Neeraj K.,Gondaliya, Bhagirath J.,Elizabeth Sobhia,Bhutani, Kamlesh K.,Jachak, Sanjay M.
, p. 45535 - 45544 (2015/06/02)
A new series of compounds comprising of 2,5-diaryl-1,3,4-oxadiazoles was synthesized and evaluated as potential COX-2 inhibitors. Compounds 6b, 6e, 6f, 7e and 7f were found to be the most potent and selective inhibitors of COX-2 (IC50 = 0.48-0.89 μM; SI = 67.96-132.83). Compounds 6e, 6f and 7f displayed anti-inflammatory activity superior to celecoxib in a carrageenan-induced rat paw edema assay. Structure-activity relationship analysis suggested that the compounds with methylsulfonyl moieties lead to more selective inhibition of COX-2, which is well supported by molecular docking studies. Cytotoxicity studies of the most potent compounds in RAW 264.7 and J774A.1 cells revealed cell viabilities of more than 89% when tested at the concentration of 30 μM. This journal is
NMR characterisation of five isomeric β,β′-diformyl-meso-tetraphenylporphyrins
Silva, Ana M. G.,Faustino, Maria A. F.,Silva, Tania M. P. C.,Neves, Maria G. P. M. S.,Tome, Augusto C.,Silva, Arthur M. S.,Cavaleiro, Jose A. S.
, p. 1774 - 1777 (2007/10/03)
The structural modification of Βformyl-meso-tetraphenylporphyrin derivatives was addressed. In particular, five isomeric Β,Β'-diformyl-meso-tetraphenylporphyrin derivatives and the corresponding nickel complexes were synthesized, separated and fully chara
