425669-60-9Relevant academic research and scientific papers
Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist
Xu, Yanping,Mayhugh, Daniel,Saeed, Ashraf,Wang, Xiaodong,Thompson, Richard C.,Dominianni, Samuel J.,Kauffman, Raymond F.,Singh, Jaipal,Bean, James S.,Bensch, William R.,Barr, Robert J.,Osborne, John,Montrose-Rafizadeh, Chahrzad,Zink, Richard W.,Yumibe, Nathan P.,Huang, Naijia,Luffer-Atlas, Debra,Rungta, Deepa,Maise, Dale E.,Mantlo, Nathan B.
, p. 5121 - 5124 (2007/10/03)
A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.
