425675-10-1

Upstream product

• 22320-10-1 methyl 4-(4-hydroxyphenyl)butanoate 

Downstream Products

• 425672-37-3 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide 
• 623176-93-2 2-(4-{3-[1-(3-methoxybenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid ethyl ester 
• 425672-49-7 N'-[4-(4-hydroxyphenyl)butyryl]-N-(3-methoxybenzyl)hydrazinecarboxylic acid n-propyl amide 
• 425672-55-5 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one 
• 425672-43-1 4-(4-hydroxyphenyl)butyric acid N'-(3-methoxybenzyl)hydrazide 

Relevant academic research and scientific papers

2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors

Human coxsackievirus B3 (CVB3) 3C protease plays an essential role in the viral replication of CVB3, which is a non-enveloped and positive single-stranded RNA virus belonging to Picornaviridae family, causing acute viral myocarditis mainly in children. During optimization based on SAR studies of benserazide (3), which was reported as a novel anti-CVB3 3Cpro agent from a screening of compound libraries, the 2,3,4-trihydroxybenzyl moiety of 3 was identified as a key pharmacophore for inhibitory activity against CVB3 3Cpro. Further optimization was performed by the introduction of various aryl-alkyl substituted hydrazide moieties instead of the serine moiety of 3. Among the optimized compounds, 11Q, a 4-hydroxyphenylpentanehydrazide derivative, showed the most potent inhibitory activity (IC50 Combining double low line 0.07 μM). Enzyme kinetics studies indicated that 11Q exhibited a mixed inhibitory mechanism of action. The antiviral activity against CVB3 was confirmed using the further derived analogue (14b) with more cell permeable valeryl ester group at the 2,3,4-trihydroxy moiety.

Peroxisome proliferator activated receptor alpha agonists

The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alky