425686-79-9Relevant academic research and scientific papers
Diastereoselective synthesis of s-tert-butyl-β-(trifluoromethyl)isocysteine
Ohkura, Hironari,Handa, Michiharu,Katagiri, Toshimasa,Uneyama, Kenji
, p. 2692 - 2695 (2002)
Both diastereoisomers of S-tert-butyl-β-(trifluoromethyl)isocysteine have been synthesized stereoselectively by the sequential reactions of trifluoroacetimidoyl chloride with the lithium enolate of tert-butyl α-tertbutylthioacetate, followed by the diastereoselective reduction of the imino group with sodium borohydride in the presence of zinc(II) or di(ethylene glycol) dimethyl ether, and finally by the deprotection of N-aryl and tert-butyl ester groups.
