42574-70-9

Usage

Uses

Used in Pharmaceutical Industry:
CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID is used as a key intermediate in the synthesis of various drugs, particularly those targeting neurological disorders and mental health conditions.
Used in Neurological Disorder Treatment:
In the field of neurology, CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID is used as a therapeutic agent for the treatment of neurological disorders. Its unique chemical structure allows it to modulate specific biological pathways and receptors, offering potential benefits in managing the symptoms and progression of these conditions.
Used as an Antipsychotic Agent:
CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID is utilized as an antipsychotic agent, demonstrating efficacy in the management of psychotic symptoms associated with various mental health disorders. Its ability to interact with specific neurotransmitter systems and receptors contributes to its antipsychotic properties, making it a valuable compound in the development of novel psychiatric medications.
Further research and studies are being conducted to explore additional applications and potential synergistic effects of CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID in combination with other therapeutic agents, aiming to enhance its therapeutic potential and broaden its scope in the medical field.

InChI:InChI=1/C9H14N2O3/c1-10-4-6-11(7-5-10)8(12)2-3-9(13)14/h2-3H,4-7H2,1H3,(H,13,14)/b3-2-

Upstream product

• 109-01-3 1-methyl-piperazine 
• 108-31-6 maleic anhydride 

Downstream Products

• 1313395-65-1 (Z)-4-(4-methylpiperazin-1-yl)-4-oxo-N-(m-tolyl)but-2-enamide 
• 1313395-76-4 (E)-4-(4-methylpiperazin-1-yl)-4-oxo-N-(m-tolyl)but-2-enamide 

Relevant academic research and scientific papers

Experimental and theoretical investigation of the reaction of secondary amines with maleic anhydride

The reaction of secondary amines, namely 1-methylpiperazine, pyrrolidine, morpholine, 2-methylpiperidine, and diethylamine, with maleic anhydride has been investigated experimentally and theoretically at the DFT level. Under kinetic control, i.e. at -78°C

A rapid and simple amine-catalyzed microwave-assisted isomerization of maleamides into fumaramides

An improved, efficient, and simple method for the synthesis of nonsymmetrical diamides of fumaric acid is reported. Starting from commercially available substrates, maleic diamides are formed in two steps, and then isomerized in a focused microwave reactor in acetonitrile as the solvent in the presence of a catalytic amount of piperidine, giving the corresponding fumaramides in high yields and purity.

A facile precursor route to transition metal molybdates using a polyzwitterionic matrix bearing simultaneously charged moieties and complexing groups

An unconventional but easily accessible precursor route involving the thermal treatment of hybrid precursors containing an ampholytic polymer matrix is developed to prepare multimetallic oxides of catalytic interest such as transition metal molybdates. A copolymer of diallyldimethylammonium chloride and a functionalized maleamic acid bearing an amine group suited for cation complexation was designed, synthesized and used as a matrix to stabilize inorganic species generated in solution from Ni(NO3) 2·6H2O, Co(NC3)2· 6H2O and/or Mn(NO3)2·4H2O together with (NH4)6Mo7O24· 4H2O. UV-vis-NIR as well as 13C-NMR studies suggest that the interactions between the cations and the polymer in solution are mainly electrostatic. Only minor complexation interactions take place under certain conditions. Homogeneous hybrid blends were prepared from these solutions. The presence of a complexing amine group in addition to the charged betaine moieties in the polymer permits stabilization of more than stoichiometric amounts of the metal species in the blends. XRD measurements suggest that the homogeneity in the solid state can be kept up to about 1.5 mol of each metal that is incorporated (anionic as well as cationic) per mol of repeat units of the copolymer. The blends were calcined under air at 600°C to produce the simple as well as mixed nickel, cobalt and manganese molybdates. Characterization of the final phases by XRD and Raman spectroscopy indicates that the α- as well as the β-molybdate phases can be prepared, and that the mixed structures are solid solutions of the simple NiMoO4, MnMoO 4 and CoMoO4 If the precursors engaged are homogeneous, the pH of the precursor solution, the amount of metal that is incorporated in the matrix, and the nature of the polymer matrix seem to exert only a minor influence on the nature of the final phase, which demonstrates the versatility and facile applicability of the method. The Royal Society of Chemistry 2005.