42594-54-7

Upstream product

• 2431-91-6 4-methoxy-2,6-dimethylphenol 

Downstream Products

• 42594-55-8 4-Benzyloxy-2-brom-3,5-dimethylanisol 
• 42594-56-9 (3-Benzyloxy-6-methoxy-2,4-dimethyl-phenyl)-(2,6-dimethoxy-phenyl)-methanone 
• 42594-58-1 (2,6-Dimethoxy-phenyl)-(3-hydroxy-6-methoxy-2,4-dimethyl-phenyl)-methanone 
• 42594-59-2 (3,6-Dihydroxy-2,4-dimethyl-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone 
• 42594-60-5 (3,6-Dihydroxy-2,4-dimethyl-phenyl)-(2,6-dihydroxy-phenyl)-methanone 
• 42594-62-7 2-(2,6-Dihydroxy-benzoyl)-3,5-dimethyl-[1,4]benzoquinone 

Relevant academic research and scientific papers

Diversity-Oriented Synthesis of Spiroannulated Benzofuran-3-one Scaffold of Leptosphaerin C and Congeners via Aryne Insertion

A concise synthesis of functionalized cyclohexenone-fused spirobenzofuran-3-ones under mild reaction conditions was developed. The reaction proceeds via insertion of aryne into the C-O bond followed by a regioselective intramolecular conjugate addition. The use of silyl-protected acid was crucial for the transformation. This protocol was successfully applied for the synthesis of leptosphaerin C core and its novel analogues.