42600-84-0

Basic information

• Product Name: N-[3-(trifluoromethyl)phenyl]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
• Synonyms: N-[3-(Trifluoromethyl)phenyl]adamantane-1-carboxamide; tricyclo[3.3.1.1~3,7~]decane-1-carboxamide, N-[3-(trifluoromethyl)phenyl]-
• CAS NO: 42600-84-0
• Molecular Formula: C₁₈H₂₀F₃NO
• Molecular Weight: 323.3527
• Mol File: 42600-84-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 436.4°C at 760 mmHg
• Flash Point: 217.7°C
• Density: 1.312g/cm³
• Vapor Pressure: 8.1E-08mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: N-[3-(trifluoromethyl)phenyl]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(trifluoromethyl)phenyl]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide(42600-84-0)
• EPA Substance Registry System: N-[3-(trifluoromethyl)phenyl]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide(42600-84-0)

Safety Data

• Hazardous Substances Data: 42600-84-0(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 2094-72-6 1-Adamantanecarbonyl chloride 
• 828-51-3 1-Adamantanecarboxylic acid 

Relevant articles and documents

Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion

Two series of easily accessible anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activity relationship were performed. The compounds were shown to interfere with low pH-induced membrane fusion mediated by the H1 and H5 (group 1) hemagglutinin (HA) subtypes. A combination of virus resistance, HA interaction, and molecular dynamics simulation studies elucidated the binding site of these aniline-based influenza fusion inhibitors, which significantly overlaps with the pocket occupied by some H3 HA-specific inhibitors, indicating the high relevance of this cavity for drug design.