426219-51-4

Basic information

• Product Name: Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI)
• Synonyms: Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI);Imidazo[1,5-a]pyridin-8(5H)-one,6,7-dihydro-;6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one;6,7-Dihydroimidazo[1,5-a]pyridin-8(5H)-one
• CAS NO: 426219-51-4
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15122
• Product Categories: AMINETERTIARY
• Mol File: 426219-51-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 356.957 °C at 760 mmHg
• Flash Point: 169.682 °C
• Appearance: /
• Density: 1.351 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: 2-8°C
• PKA: 4.14±0.20(Predicted)
• CAS DataBase Reference: Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI)(426219-51-4)
• EPA Substance Registry System: Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI)(426219-51-4)

Safety Data

• Hazardous Substances Data: 426219-51-4(Hazardous Substances Data)

Usage

General Description

Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI) is a chemical compound with the molecular formula C8H7N3O. It is a heterocyclic compound that contains both nitrogen and oxygen atoms in its ring structure. Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI) has potential pharmaceutical applications as it possesses diverse pharmacological activities such as anticancer, antiviral, antidiabetic, and anti-inflammatory properties. It has also been studied for its role as a ligand for metal ion coordination and as a precursor for the synthesis of various organic compounds. Additionally, this compound has shown potential as a fluorescent probe for detecting the presence of metal ions in biological systems. Imidazo[1,5-a]pyridin-8(5H)-one, 6,7-dihydro- (9CI) is an important molecule with a wide range of potential applications in various fields including medicinal chemistry, biochemistry, and materials science.

InChI:InChI=1/C7H8N2O/c10-7-2-1-3-9-5-8-4-6(7)9/h4-5H,1-3H2

Upstream product

• 38666-30-7 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine 
• 910094-98-3 8-benzyloxy-imidazo[1,5-a]pyridine 

Downstream Products

• 426219-57-0 8-(4-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol 
• 916572-27-5 8-[3-(4-methoxyphenyl)propyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol 
• 1067882-45-4 8-[2-(tert-butyl-dimethyl-silanyloxymethyl)-5-chloro-phenyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-8-ol 
• 1067882-40-9 8-(4-bromo-2-hydroxymethyl-phenyl)-5,6,7,8-tertrahydro-imidazo[1,5-a]pyridin-8-ol 
• 940879-62-9 8-[4-(1,1-dimethoxyethyl)phenyl]-5,6,7,8-tetrahvdroimidazo[1,5-a]pyridin-8-ol 

Relevant articles and documents

Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One

6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.

Novel imidazole derivatives, production method thereof and use thereof

The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula: wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.