4264-04-4Relevant academic research and scientific papers
3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS
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Page/Page column 39, (2009/08/16)
The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-A RECEPTOR COMPLEX
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Page 22, (2010/02/08)
This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disord
BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
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Page/Page column 16, (2010/02/08)
This invention relates to novel benzimidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
SYNTHESIS OF 3-ARYL-4,5-DIHYDRO-5-HYDROXY-1,2-OXAZOLES BY REACTION OF SUBSTITUTED BENZONITRILE OXIDES WITH THE ENOLATE ION OF ACETALDEHYDE.
Di Nunno, L.,Scilimati, A.
, p. 2181 - 2190 (2007/10/02)
By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n-butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields.Treatment of such hydroxy-isoxalines with some common bases allows their conversion in high yields into the corresponding isoxazoles.
SYNTHESIS AND PROPERTIES OF AZOLS AND THEIR DERIVATIVES. PART VI. CYCLOADDITION REACTIONS OF NITROETHYLENE WITH AROMATIC NITRILE N-OXIDES AND SOME CONVERSIONS OF 3-ARYL-5-NITRO-4,5-DIHYDRO-1,2-OXAZOLES
Baranski, Andrzej,Shvekhgeimer, Genrikh A.
, p. 459 - 467 (2007/10/02)
Reactions of aromatic nitrile N-oxides with nitroethylene lead to formation of 3-aryl-5-nitro-4,5-dihydro-1,2-oxazoles.During heating the above compounds decompose with elimination of nitrous acid, thus affording 3-aryl-1,2-oxazoles.Under nucleophilic reagents a ring opening was observed.
