4264-28-2Relevant academic research and scientific papers
Synthesis of 1: H -indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids
Zhang, Xiaoxiang,Li, Ping,Lyu, Chang,Yong, Wanxiong,Li, Jing,Zhu, Xinbao,Rao, Weidong
, p. 6080 - 6083 (2017)
An efficient method for the synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids has been developed. The desired products were obtained in good to excellent yields under mild reaction con
Synthesis of N-Fused Seven-Membered Indoline-3-ones via a Palladium-Catalyzed One-Pot Insertion Reaction from 2-Alkynyl Arylazides and Cyclic β-Diketones
Hu, Guiwen,Li, Ping,Sheng, Rong,Zhang, Xiaoxiang,Zhou, Zhiqiang
supporting information, (2020/04/08)
A novel strategy to synthesize N-fused seven-membered multifunctional polycyclic indoline-3-one derivatives via insertion of cyclic C-acylimines into cyclic β-diketones has been described. The reaction proceeded well under mild reaction conditions via a one-pot, three-steps method, which has shown good tolerance of various functional groups.
Pd-Catalyzed One-Pot Insertion Reaction of Cyclic C-Acylimines into Carbon-Carbon σ-Bonds for the Synthesis of Polyfunctional Indolin-3-ones from 2-Alkynyl Arylazides and Aryl Ketones
Li, Ping,Yong, Wanxiong,Sheng, Rong,Rao, Weidong,Zhu, Xinbao,Zhang, Xiaoxiang
, p. 201 - 207 (2018/11/27)
A method to prepare polyfunctional indolin-3-ones by Pd-catalyzed one-pot insertion reaction of cyclic C-acylimines into carbon-carbon σ-bonds is described. The reaction was accomplished in good to excellent yields under mild reaction conditions. (Figure presented.).
Palladium-Catalyzed One-Pot Synthesis of C2-Quaternary Indolin-3-ones via 1H-indole-3-sulfonates Generated in Situ from 2-Alkynyl Arylazides and Sulfonic Acids
Zhang, Xiaoxiang,Li, Ping,Lyu, Chang,Yong, Wanxiong,Li, Jing,Pan, Xinyu,Zhu, Xinbao,Rao, Weidong
supporting information, p. 4147 - 4152 (2017/12/15)
A novel method for the synthesis of C2-quaternary indole-3-ones via palladium-catalyzed one-pot transformation of 2-alkynyl arylazides is described. The reaction produced in moderate to excellent yields under mild conditions. This novel rearrangement of 1-H-indole-3-sulfonates represents an important contribution to the application of aryl sulfonates. (Figure presented.).
STUDIES ON TERTIARY AMINE OXIDES. LXXII. SOME NUCLEOPHILIC REACTIONS OF 1-HYDROXY-2-PHENYLINDOLE
Nagayoshi, Tsuyoshi,Saeki, Seitaro,Hamana, Masatomo
, p. 1920 - 1926 (2007/10/02)
1-Hydroxy-2-phenylindole (1) reacts with tosyl chloride and p-nitrobenzenesulfonyl chloride in DMF-pyridine to give the corresponding 2-phenyl-3-sulfonyloxyindole (2 and 4).Benzoyl chloride is less reactive, and 1-benzoyloxy-2-phenylindole (5) or 3-benzoyloxy-2-phenylindole (6) is formed, depending upon the reaction conditions. 3-Acetoxy-2-phenylindole (7) is also obtained by refluxing 1 with acetic anhydride or with acetyl chloride in DMF-pyridine.Treatment of 1 with tosyl chloride and then with 1-morpholinocyclohexene (9), ethyl acetoacetate (17) and ethyl cyanoacetate (20) in DMF-pyridine at room temperature affords 3-(2-oxocyclohexyl)-2-phenylindole (10), ethyl α-(2-phenyl-3-indolyl)acetoacetate (18) and ethyl α-(2-phenyl-3-indolyl)cyanoacetate (21) in 23.2, 41 and 61percent yields, respectively.Keywords: enehydroxylamine system; 1-acyloxy-2-phenylindole; 3-acyloxy-2-phenylindole; 1-morpholinocyclohexene; 3-(2-oxocyclohexyl)-2-phenylindole; ethyl α-(2-phenyl-3-indolyl)acetoacetate; ethyl α-(2-phenyl-3-indolyl)cyanoacetate
