4267-07-6

Usage

Chemical class

Benzodiazepine

Structure

1H-1,4-Benzodiazepine, 7-chloro-2,3,4,5-tetrahydro-1-methyl-5-phenyl-

Central nervous system effect

Depressant

Sedative properties

Yes

Hypnotic properties

Yes

Anxiolytic properties

Yes

Muscle relaxant properties

Yes

Common uses

Treatment of anxiety, insomnia, seizures, and muscle spasms

Potential for addiction

Yes

Dependence risk

High

Withdrawal symptoms

Possible

Recommended use

Under the guidance of a healthcare professional

Upstream product

• 439-14-5 diazepam 
• 1694-79-7 7-chloro-1-formyl-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine 

Relevant academic research and scientific papers

Process for preparing 1,4-benzodiazepines

1,4-Benzodiazepine derivatives of the formula, STR1 wherein R1 is hydrogen, a lower alkyl, a haloalkyl, a cycloalkylalkyl, an alkoxyalkyl, an acyloxyalkyl, an alkylthioalkyl, an alkylaminoalkyl, a dialkylaminoalkyl, a hydroxyalkyl, carbamoyl, or an N-alkylcarbamoyl; R2 is hydrogen or a lower alkyl; X is hydrogen, a halogen, nitro, or trifluoromethyl; A is a group of the formula, STR2 (wherein Y and Z each represent hydrogen, a halogen, a lower alkyl, or nitro) and a salt thereof, are prepared by reacting a 1,4-benzodiazepin-2-one compound of the formula, STR3 wherein R1, R2, X, Y and Z are the same as defined above, with diborane in an inert solvent.

Preparation of benzodiazepines

A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-am